Histidine and Immunotherapy Response in Colorectal Cancer
Part of Cancer, Digestive system clinical trials.
This study explores whether a nutrient called histidine affects how well immunotherapy (a type of cancer-fighting treatment) works in colorectal cancer patients. Researchers will examine blood and tissue samples to understand this connection and potentially improve treatment outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be at least 18 years old
- Have colorectal cancer confirmed by biopsy or colonoscopy, or have previously received PD-1 immunotherapy for colorectal cancer
- Not have uncontrolled high blood pressure, diabetes, high cholesterol, or thyroid problems
- Not have inflammatory bowel disease, Crohn's disease, or other serious digestive conditions
- Not have a history of other cancers or certain genetic bowel syndromes
- Not have a history of seizures, epilepsy, or serious depression
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether taking a histidine supplement (an amino acid building block) alongside standard colorectal cancer treatment helps your immune system fight the cancer better. Researchers want to see if this simple addition can improve outcomes for people with stage II or higher colorectal cancer.
This trial tests a treatment made from your own immune cells (called TILs) that are taken from your tumor, grown in a lab, and given back to you along with immunotherapy. It is for people with advanced colon or rectum cancer who have run out of standard options.
This study looks at how gut bacteria and immune activity differ in normal, pre-cancer, and cancer colon tissue. It may help researchers understand what changes in the body are linked to colon growth and how they could be targeted in the future.
This study uses blood and tumor samples to find markers that predict whether immunotherapy will work for people with stage IV cancer. The goal is to better match treatments to patients.
This trial tests how your body's immune system reacts to a treatment called histotripsy for colorectal cancer that has spread to the liver. Histotripsy uses sound waves to break apart tumors, and the study aims to see if this can help your immune system fight the cancer better.
This study collects tumor samples and medical information from patients with liver cancer to understand why some patients respond better to immunotherapy (immune-boosting drugs) than others. The goal is to improve treatment selection and outcomes for future patients.
Hear when a new Colorectal cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.