Capsaicin cream for chemo-related nerve pain in legs
Treatments studied
Part of Brain & nervous system, Cancer, Pain clinical trials.
This study tests whether an 8% capsaicin cream (a chili-pepper derived treatment) can help reduce nerve pain and numbness in the legs caused by cancer chemotherapy drugs (taxanes). The cream is applied directly to affected areas, and the research team will track whether it improves your symptoms and pain levels over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You experienced nerve damage (numbness, tingling, or pain) in your lower legs from taxane chemotherapy (paclitaxel or docetaxel) at least 3 months ago
- You have ongoing nerve pain in your legs rated as moderate or higher on a 0–10 pain scale, and it meets certain neuropathy criteria (DN4 score ≥4)
- You can attend all study visits and follow the treatment plan for the full study duration
- You speak and read French fluently and can give informed consent
- Your pain-relief medications have been stable for at least 2 weeks (or you take none), and you are willing to keep them unchanged during the study
- You do not have another cause of nerve damage, such as untreated diabetes, kidney disease, or alcohol-related nerve damage
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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