Amnioinfusion to Protect Baby Brains in Uterine Infection
Part of Genetic & congenital, Women’s health & pregnancy clinical trials.
This trial tests whether flushing the amniotic sac (the fluid surrounding the baby) with saline solution can reduce brain injury when a mother develops a uterine infection during labor. The goal is to see if this simple treatment protects the baby's developing brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and pregnant with one baby (not twins or multiples)
- You are at least 36 weeks pregnant and currently in active labor
- You have been diagnosed with chorioamnionitis (a uterine infection) shown by fever of 100.4°F or higher plus at least one sign like high white blood cell count, discharge, or baby's fast heart rate
- Your cervix is dilated enough to allow a small monitoring tube to be safely placed in the uterus
- Your baby does not have a known major birth defect and can safely be born vaginally
- You do not have placenta previa (placenta covering the cervix) and your baby's heart tracing is not in critical distress requiring immediate delivery
- You are English-speaking and able to understand and sign informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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