Drug combination before surgery for recurrent head and neck cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests three drugs (finotonlimab, cetuximab, and docetaxel) given before surgery to remove recurrent head and neck cancer in patients whose cancer stopped responding to previous immunotherapy. The goal is to shrink the tumor and improve surgical outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have recurrent head and neck squamous cell carcinoma (cancer of the lining of the mouth, throat, or voice box) that has grown back after prior treatment
- Your cancer must have stopped responding to both immunotherapy (PD-1/PD-L1 inhibitors) and platinum-based chemotherapy given previously
- Your tumor must be removable by surgery with no spread to distant body parts, as confirmed by your medical team
- You must have acceptable organ function (blood counts, liver, kidney, and heart function) measured within one week before starting
- You must be willing to provide a tumor sample (either archived tissue or a fresh biopsy) for testing
- You must be generally healthy enough for treatment (ECOG performance score 0–1, life expectancy over 3 months)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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