Combination drug therapy before surgery for recurrent head and neck cancer
Treatments studied
Part of Cancer clinical trials.
This trial is testing a combination of two drugs (becotatug vedotin and pucotenlimab) given before surgery to shrink recurrent head and neck cancer that has stopped responding to prior immunotherapy and chemotherapy. The goal is to see if this approach helps make the tumor removable and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have recurrent head and neck squamous cell carcinoma that has progressed after treatment with both an immunotherapy (PD-1/PD-L1 inhibitor) and a platinum-based chemotherapy.
- Your tumor tests positive for EGFR protein, and you haven't had EGFR-targeted therapy in the last 6 months.
- You have at least one measurable tumor that isn't in the brain, and it can be removed by surgery.
- Your overall health is good enough for surgery and study drugs, with adequate organ function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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