Nitrous Oxide vs Lidocaine for Pain Relief During Needle Procedures
Treatments studied
Part of Mental health, Pain clinical trials.
This study compares two pain-relief methods—nitrous oxide gas (laughing gas) and lidocaine numbing cream—to see which works better when doctors need to place a needle in your vein. If you've never used nitrous oxide before and are generally healthy, you may be a good fit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have never used nitrous oxide (laughing gas) before
- You are between 18 and 65 years old
- You do not have an infection at the site where the needle will go
- You are not pregnant and do not have high pressure in your brain, B12 deficiency, or blood disorders
- You have a normal mental awareness (able to answer simple questions correctly) and a healthy weight (BMI of 35 or less)
- You do not have chronic pain or neurological conditions like seizures or severe nerve problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether self-adjusting nitrous oxide (a calming gas) with oxygen can be safely and comfortably used during a vasectomy, and how people experience it. You may be offered the gas to see how it fits into care during the procedure.
This trial compares self-administered nitrous oxide gas with a placebo to see if it helps reduce pain and anxiety during a vasectomy done in the doctor's office. It aims to find a better way to manage discomfort without stronger medications.
This study tests whether an ultrasound-guided numbing injection in the belly wall can reduce pain during heart procedures like angioplasty or stent placement. It is for people having planned (non-emergency) heart catheterization.
This early-stage study tests whether using disposable nitrous oxide canisters can better control pain when you need burn dressing changes. It may help by making dressing changes more comfortable, but eligibility depends on your burn size, health, and breathing ability.
This study compares two ways to numb the skin before placing an epidural needle: a lidocaine patch placed on the back versus a lidocaine injection under the skin. The goal is to find which method is more comfortable for pregnant women during labor or cesarean delivery.
This study tests a numbing medicine to reduce pain when inserting the birth control implant Nexplanon. It may help women who are getting Nexplanon for the first time and are not using pain medications.
Hear when a new Acute Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.