Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07562412Recruiting
Audio Mindfulness for Quick Pain Relief
This study tests whether listening to brief guided mindfulness audio recordings can help reduce acute (sudden, short-term) pain. Researchers will see how different amounts of listening affect pain levels.
Tallahassee, FloridaAges 18 years+ - NCT05819476Recruiting
Testing how open-label placebos affect induced pain
This study tests whether people can feel less pain when they know they are receiving a “placebo” (a treatment with no active pain-relieving medicine). It’s done in healthy adults by triggering short-lasting pain in a controlled way to see how the placebo effect changes pain feelings.
BaselAges 18–65 - NCT06160778RecruitingPhase 3
Comparing two pain medicines for kids with belly pain
This study compares two common pain relievers—ketorolac and morphine—given through an IV to children with acute abdominal pain. It aims to find which works better and has fewer side effects for this condition.
Calgary, AlbertaAges 6–17 - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT06471075Recruiting
Mindfulness for Pain Before Orthopedic Procedure
This study tests whether a short mindfulness (calm focus) exercise before an in-clinic orthopedic procedure can help reduce pain. If you are getting kyphoplasty or radiofrequency ablation at Tallahassee Orthopedic Center, this brief program might make your experience more comfortable.
Tallahassee, FloridaAges 18 years+ - NCT06555107Recruiting
Pain before emergency surgery and long-term pain after
This study looks at whether pain you feel before emergency surgery affects long-term pain after the surgery. It may help doctors find ways to prevent chronic pain in patients who have emergency orthopedic (bone/joint) or abdominal (belly) surgery.
AmiensAges 18 years+ - NCT07024199RecruitingPhase 4
Pain relief for children with acute pancreatitis
This trial compares three common pain relievers (paracetamol, ibuprofen, and metamizole) to see which works best for children with acute pancreatitis. It aims to help your child feel better faster with fewer side effects.
WarsawAges 3–18 - NCT07336264Recruiting
Understanding acute pain in children
This study looks at how children and teens experience pain after surgery or during a bone marrow transplant. It aims to better understand acute pain, which is short-term pain that goes away as the body heals.
Washington D.C., District of ColumbiaAges 6–21 - NCT06949059RecruitingPhase 1/Phase 2
Hydromorphone for acute chest pain relief
This trial tests a quick-acting pain medicine (hydromorphone) given through a vein to treat severe chest pain. It may be an option for people experiencing acute pain who haven't been helped by other medicines.
Nanjing, JiangsuAges 18–64 - NCT05266040RecruitingPhase 2
Valacyclovir to reduce pain from infected tooth abscess
This Phase 2 study tests whether valacyclovir, an antiviral medicine, can help reduce moderate-to-severe pain from an acute infected tooth abscess. Participants also receive standard dental treatment, and the study looks at whether the added medicine helps with pain.
San Francisco, CaliforniaAges 18–80 - NCT05555576Recruiting
Vitamin C to reduce opioid use after an ER visit
This trial tests whether taking vitamin C after an emergency room visit for a new, short-term muscle or joint pain can lower how many opioid pain pills you use. It may help by reducing opioid consumption while you recover.
Montreal, QuebecAges 18 years+ - NCT07310953Recruiting
Using new pain scales to guide rescue pain medicine after surgery
This trial tests if a simple pain scale (the NVS and PFAS) can help doctors better decide when to give extra pain medicine after surgery. It may help control pain more quickly and effectively after a procedure called VATS.
VigoAges 18 years+ - NCT07472296Recruiting
Comparing nerve blocks for heart surgery pain relief
This trial compares different types of nerve blocks to see which works best for managing pain after heart surgery through the breastbone. It may help reduce the need for strong pain medications.
Bursa, NilüferAges 18–80 - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT06569953RecruitingPhase 4
Numbing Medicine for Pain After Lung Surgery
This study tests whether a long-lasting numbing medicine (liposomal bupivacaine) injected near the spine can better control pain after lung surgery. It compares this to a standard numbing medicine, and aims to help patients recover with less pain after surgery.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT07198412Recruiting
Study on sedation's effect on back pain after spinal anesthesia
This study looks at whether giving sedation (medicine to help you relax) during spinal anesthesia can reduce back pain after surgery. It's for people having certain types of surgery on their lower abdomen or legs.
Banhā, Qalyubia GovernorateAges 18–65 - NCT07344090Recruiting
Using a decision tool to manage fever and pain in children
This trial tests a decision-making system to help parents manage fever and acute pain in young children. It's for children aged 3 months to 5 years who need paracetamol for fever or pain.
Florence, ItalyAges 3 months–5 years - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT06602271RecruitingPhase 3
Study of PF614 for Pain After Tummy Tuck Surgery
This study tests a new painkiller called PF614 for pain after tummy tuck surgery. It compares the study drug to a placebo (a pill with no medicine) to see how well it works and how safe it is.
Atlanta, GeorgiaAges 18–75 - NCT06364540RecruitingPhase 4
Ketamine vs fentanyl for severe pain in the ER
This trial compares two inhaled pain relievers, ketamine and fentanyl, to see which works better for sudden, severe pain in the emergency room. You would receive one of these medicines through a breathing mask to help your pain quickly.
Brooklyn, New YorkAges 18–120 - NCT06854991Enrolling by invitation
Virtual reality for managing pain in healthy kids
This study tests if virtual reality can help distract children and teenagers from the feeling of pain. It could show that VR is a helpful tool for managing pain without medicine.
Columbus, OhioAges 6–17 - NCT06503523Recruiting
Brain activity during pain and itch
This study tests whether imagining movements changes brain activity when you feel pain or itch. It could help scientists understand how the brain responds to these sensations.
GistrupAges 18–60 - NCT07650591Recruiting
Tapping and vibration to ease needle pain in children
This study tests whether rhythmic tapping and gentle vibration near the skin can help children ages 6–12 feel less pain and fear during blood draws. Researchers want to see if these simple techniques can make the procedure more comfortable.
Antalya, KepezAges 6–12
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Acute Pain trials by city
Studies with a site in or near these metro areas.
Acute Pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 212 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.