Non-opioid pain reliever after knee replacement surgery
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests a new non-opioid pain reliever (suzetrigine) combined with other standard treatments to control pain after knee replacement surgery, with the goal of reducing opioid use. If effective, it could offer better pain control with fewer opioid-related risks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having a total knee replacement because of knee osteoarthritis.
- You are between 18 and 95 years old.
- You have not been taking opioid pain medications daily for the past 4 weeks or longer.
- You do not have serious heart, kidney, or liver disease, active stomach ulcers, or diabetes (A1C above 6.5%).
- You are not taking blood thinners other than aspirin (81 mg twice daily).
- You are not pregnant and can safely take nonsteroidal anti-inflammatory drugs (NSAIDs).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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