Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,834 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3150
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis183
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York95
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,834 total
- NCT00029965Recruiting
Understanding rare storage diseases over time
This study follows people with rare genetic conditions (GM1, GM2, sialidosis, or galactosialidosis) that affect how the body breaks down certain substances in cells. Researchers track how these diseases progress to better understand them and potentially help future patients.
Bethesda, MarylandAges 1 day–100 years - NCT00001727Recruiting
Understanding fibrous dysplasia and McCune-Albright syndrome
This study follows patients with fibrous dysplasia (a condition where normal bone is replaced by fibrous tissue) or McCune-Albright syndrome (a genetic condition affecting bone, skin, and hormones) to understand how these conditions develop and progress over time. There is no experimental treatment; researchers simply want to learn more about these rare conditions.
Bethesda, MarylandAges 1 day–100 years - NCT02504853Recruiting
Study food allergy patterns and genetics over time
This study follows people with food allergy and some closely related or healthy people to learn how food allergy (and related conditions) develops over time. It may help researchers find causes and better ways to predict and treat food allergy.
Bethesda, MarylandAges 1 day–99 years - NCT06964880Recruiting
Peer support program for obesity and muscle loss awareness in college students
This study tests whether a peer support program (using videos and messages) can help college students become more aware of obesity and muscle loss. It is for students at one university in central Taiwan who are slightly overweight or have higher body fat, and who are otherwise healthy.
TaichungAges 18–25 - NCT06928077Recruiting
Power wheelchair training for toddlers with motor delays
This study tests whether adding special visual cues (like lights or arrows) to a power wheelchair helps toddlers with motor delays learn to drive it. If your child is between 1 and 3 years old, can't walk on their own, and can reach for toys, they may be a good fit.
Taoyuan City, Taoyuan CountyAges 10 months–3.3 years - NCT06924801Recruiting
Motion tracking game for kids in physical therapy
This trial tests if a fun, motion-tracking game can help kids aged 6-17 who are already in physical therapy at Stanford Children's Hospital. It looks at how real-time feedback might improve their rehab.
Palo Alto, CaliforniaAges 6–17 - NCT06909513Enrolling by invitation
Can a travel neck pillow help after thyroid surgery?
This study tests if using a travel neck pillow after thyroid surgery improves neck comfort and movement. It may help you recover more easily if you are having your thyroid removed.
Kayseri, TalasAges 18 years+ - NCT06685666Recruiting
Band exercises for better shooting in handball
This study tests if adding band exercises to the warm-up routine can improve shooting accuracy and the health of arm muscles in young female handball players.
Istanbul, MaltepeAges 12–18 - NCT06648616Recruiting
Resistance band training for female footballers
This study tests if elastic band exercises can improve performance in women football players. If you play in a top Portuguese league, you may be eligible.
Maia, Porto DistrictAges 18 years+ - NCT06625424Recruiting
Short sprints with active recovery for non-athletes
This study tests whether doing very short, all-out sprints with active recovery (like walking or light jogging) improves your body's ability to perform high-intensity exercise better than resting between sprints. It is for healthy young adults who are not competitive athletes.
Rawalpindi, Punjab ProvinceAges 18–25 - NCT06152497Recruiting
Histamine and muscle growth after strength training
This study looks at how histamine affects muscle building after resistance exercise. It may help us understand why some people build muscle better than others after strength training.
Ghent, Oost-VlaanderenAges 18–45 - NCT07132775Recruiting
Full-body electrical stimulation suit for spasticity and pain
This study tests a full-body suit that delivers gentle electrical pulses to help reduce muscle stiffness, spasms, and pain in people with conditions like multiple sclerosis, fibromyalgia, or other neurological problems. It may help with movement and comfort.
Chicago, IllinoisAges 18–75 - NCT06004804Recruiting
Psychological treatments for chronic pain in veterans
This study compares two group psychological treatments for chronic pain delivered over video conference. It aims to see if these treatments help reduce pain and improve quality of life for veterans.
West Los Angeles, CaliforniaAges 60–95 - NCT07793526Recruiting
Work return program for muscle and joint pain
This study tests a program to help people on sick leave because of muscle or joint pain get back to work sooner. It focuses on those at high risk of being off work for a long time and may offer extra support during your recovery.
UtrechtAges 18–65 - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Birmingham, AlabamaAges 18–75 - NCT07111065RecruitingPhase 2
Fatty Acid Supplement for Dermatomyositis
This study tests whether taking a fatty acid supplement (omega-3) for 6 months can help reduce disease activity in people with dermatomyositis. Participants will also receive dietary coaching and have regular check-ups at the NIH to monitor their progress.
Bethesda, MarylandAges 18–60 - NCT06925542RecruitingPhase 1
Study of CTX112 for adults with autoimmune disease
This trial tests an experimental cell therapy called CTX112 for people with lupus, scleroderma, or inflammatory myositis that hasn't responded well to standard treatments. The goal is to see if it's safe and if it can help control the disease.
La Jolla, CaliforniaAges 18–70 - NCT07654751RecruitingPhase 4
Study of Tremfya in breast milk of breastfeeding women
This study measures how much Tremfya (guselkumab) gets into breast milk for women who are already taking it for conditions like psoriasis or arthritis and choose to breastfeed. It helps understand if the drug passes to the baby.
Chapel Hill, North CarolinaAges 18 years+ - NCT06323980Recruiting
Study of a new stemless shoulder replacement
This trial tests a new shoulder replacement system that does not require a stem (a long piece that goes into the arm bone). It is for patients with severe shoulder arthritis or rotator cuff problems. The study will see how well the device works and how it compares to other treatments.
Atlantis, FloridaAges 22 years+ - NCT06779188RecruitingEarly Phase 1
Brain stimulation to improve balance in older adults
This trial tests whether a non-invasive brain stimulation technique called theta burst TMS can improve balance and brain connectivity in adults over 65 who have had recent falls. It involves MRI scans, 4 weeks of treatment, and follow-up tests.
Houston, TexasAges 65 years+ - NCT07059065Recruiting
New bone graft for spinal fusion surgery
This trial tests a new bone graft material called FIBERGRAFT Aeridyan for people needing spinal fusion to stabilize their lower back. It aims to see if it helps bones heal together safely and effectively.
Sacramento, CaliforniaAges 18 years+ - NCT07363590RecruitingPhase 1
Study of MK-1045 for lupus or rheumatoid arthritis
This study tests a new drug, MK-1045, for people with lupus or rheumatoid arthritis. It aims to see if the drug is safe and how it affects your condition.
Southport, QueenslandAges 18–75 - NCT07567092Recruiting
VIRTUGUIDE System for Bunion Foot Surgery
This study tests a new computer-guided system to help surgeons perform bunion correction surgery (called a Lapidus procedure) more accurately. Participants will receive this guided surgery along with a standard implant, and researchers will track how well the surgery works and how patients recover.
Virginia Beach, VirginiaAges 22 years+ - NCT06631638Recruiting
New hip replacement study using smart navigation
This study tests a hip replacement system that uses a special navigation tool to help the surgeon place the new hip cup more precisely. It may lead to better long-term results and fewer complications.
Gainesville, FloridaAges 21 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,834 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,906 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.