Botulinum Toxin to Help Close Large Belly Wall Hernias
Part of Digestive system clinical trials.
This study tests whether injecting botulinum toxin (Botox) before surgery can help close large holes in the belly wall by relaxing the muscles and making it easier to bring the edges together. This might reduce complications and improve healing after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a large ventral hernia (a bulge or hole in your belly wall) that is at least 10 cm wide
- Your hernia is either a primary hernia (new) or an incisional hernia (from a previous surgery scar)
- You have loss of domain of at least 20% (meaning your abdominal organs have shifted and there's limited space to close the hole)
- You are willing to receive a botulinum toxin injection before surgery
- You are 18 years or older and able to understand and follow the study plan
- You do not have neuromuscular disorders, pregnancy, or allergy to botulinum toxin
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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