Botulinum Toxin to Help Close Large Belly Wall Hernias
Part of Digestive system clinical trials.
This study tests whether injecting botulinum toxin (Botox) before surgery can help close large holes in the belly wall by relaxing the muscles and making it easier to bring the edges together. This might reduce complications and improve healing after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a large ventral hernia (a bulge or hole in your belly wall) that is at least 10 cm wide
- Your hernia is either a primary hernia (new) or an incisional hernia (from a previous surgery scar)
- You have loss of domain of at least 20% (meaning your abdominal organs have shifted and there's limited space to close the hole)
- You are willing to receive a botulinum toxin injection before surgery
- You are 18 years or older and able to understand and follow the study plan
- You do not have neuromuscular disorders, pregnancy, or allergy to botulinum toxin
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if getting Botox shots in the belly muscles before hernia surgery makes the repair easier and more successful. It is for adults who need a planned, open surgery for a large ventral hernia.
This trial tests whether adding Botox injections to surgery helps repair large incisional hernias. It may lower the chance of the hernia coming back.
This trial compares different ways to prepare your body before surgery to repair a large hernia (bulge in your abdominal wall). The goal is to find the best approach to help you heal well after surgery.
This study tests a special surgery technique for people with a complex ventral hernia (a bulge in the belly wall) that cannot be fixed with standard surgery. The goal is to see if the new technique works well.
This trial tests whether giving botulinum toxin (a treatment that relaxes muscles) early after surgery can help close the abdomen more easily. It may be a good option if you have had abdominal surgery that left your belly open.
This trial tests a method to close the abdominal wall during hernia repair surgery. It looks at how your lungs and belly respond during surgery to reduce complications after a large hernia repair.
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