Botox injections before large hernia surgery
Treatments studied
Part of Digestive system clinical trials.
This trial tests if getting Botox shots in the belly muscles before hernia surgery makes the repair easier and more successful. It is for adults who need a planned, open surgery for a large ventral hernia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a scheduled, non-emergency surgery for a belly hernia.
- Your hernia is large (at least 15 cm wide or takes up over 25% of your belly space on a scan).
- Your surgery will be an open cut down the middle, with muscle separation and release.
- You are not pregnant or breastfeeding.
- You have no muscle or nerve disease, no stoma, no current infection, and no severe lung disease with oxygen use.
- Your body mass index (BMI) is 45 or lower.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares different ways to prepare your body before surgery to repair a large hernia (bulge in your abdominal wall). The goal is to find the best approach to help you heal well after surgery.
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This trial tests whether giving botulinum toxin (a treatment that relaxes muscles) early after surgery can help close the abdomen more easily. It may be a good option if you have had abdominal surgery that left your belly open.
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