Steroid-sparing nausea drug combo for high-dose chemo
Part of Cancer clinical trials.
This trial tests if combining two anti-nausea drugs (olanzapine and palonosetron) can prevent vomiting and nausea without using steroids in people receiving high-dose cisplatin chemotherapy for their first time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a solid tumor cancer confirmed by biopsy.
- You are about to receive your first round of cisplatin chemo at 50 mg/m2 or higher.
- You are not pregnant.
- You have not had radiation to your belly or pelvic area in the last 4 weeks.
- You have no untreated blockage in your gut.
- You are not allergic to palonosetron or olanzapine.
- Your liver and kidney function are within certain limits (AST/ALT not above 2.5 times normal, and creatinine clearance at least 50 ml/min).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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