Testing a drug combo for opioid-related nausea
Treatments studied
Part of Digestive system clinical trials.
This study tests whether the combination of olanzapine and metoclopramide can prevent nausea and vomiting caused by strong painkillers (opioids) in people with advanced cancer. If you are starting a strong opioid for pain and have not had nausea or vomiting recently, this study may be for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have advanced cancer that is causing moderate to severe pain (a score of 4 or more out of 10 on a pain scale).
- You must be starting a strong opioid painkiller (like morphine or oxycodone) for the first time.
- You must be at least 18 years old and able to swallow pills.
- You should not have had nausea, vomiting, or an intestinal blockage recently.
- You must not have had chemotherapy or radiation in the last month.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if combining two anti-nausea drugs (olanzapine and palonosetron) can prevent vomiting and nausea without using steroids in people receiving high-dose cisplatin chemotherapy for their first time.
This trial tests a medication called LY3537021 to see if it can prevent nausea and vomiting caused by certain types of chemotherapy (AC or cisplatin) in people who have not had chemo before. It focuses on patients who are otherwise in fairly good health.
This study tests whether a medicine called olanzapine can improve survival in people with advanced cancers of the upper digestive system or lungs. Olanzapine may help with appetite and weight, which are common problems in these cancers.
This study tests if the drug olanzapine (commonly used for nausea) can help prevent vomiting in people receiving moderately strong chemotherapy for the first time. It may be a good fit if you're about to start treatment with oxaliplatin, irinotecan, or carboplatin and haven't had severe nausea treatments before.
This study compares two anti-nausea medications, rolapitant and palonosetron, to see how well they prevent nausea and vomiting caused by chemoradiotherapy for lung cancer. It aims to help patients feel more comfortable during treatment.
This trial tests whether the drug olanzapine can help reduce side effects of chemotherapy when given before surgery for stomach cancer, potentially helping patients feel better and complete their treatment.
Hear when a new Nausea trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.