Lidocaine/prilocaine cream for pain during IUD or biopsy
Part of Brain & nervous system clinical trials.
This trial is testing a numbing cream (lidocaine and prilocaine) applied to the cervix to reduce pain during IUD insertion or endometrial biopsy. The study aims to see if this cream makes the procedure more comfortable for patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are scheduled for an IUD insertion or endometrial biopsy
- You can speak and understand English
- You are not currently pregnant
- You have not taken opioid pain medication (like codeine, oxycodone) in the last 24 hours
- You have not taken misoprostol (a medication used for cervical softening) in the last 24 hours
- You do not have a chronic pain condition such as fibromyalgia or vaginismus
- You are not allergic to lidocaine, prilocaine, or other '-caine' anesthetics
- You have no history of methemoglobinemia or G6PD deficiency
- You do not have severe kidney or liver disease
- You have no history of local anesthetic toxicity (LAST)
- Your baseline blood pressure is not low (systolic below 100 or diastolic below 60) and your pulse is not below 60
- You have not had a previous failed attempt at the same procedure by the same practitioner
- You do not have active eczema or a skin condition on the vulva, vagina, or cervix
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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