Psilocybin for methamphetamine use disorder
Part of Mental health clinical trials.
This trial tests whether psilocybin, a psychedelic substance, can help people with moderate to severe methamphetamine use disorder reduce or stop their use. It may work by helping the brain reset, but it's not a standard treatment and involves careful monitoring.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have a diagnosis of moderate or severe methamphetamine use disorder.
- You have used methamphetamine on more than 7 of the last 30 days, and had more than one positive urine test before starting.
- You want to stop using methamphetamine completely.
- You can read, write, and speak English.
- You have a friend or family member who can stay with you after the treatment sessions.
- You are in generally good health based on a medical exam.
- You have been off methamphetamine for at least 24 hours before the first treatment dose.
- You are not pregnant, breastfeeding, or if you can get pregnant, you use effective birth control.
- You do not have other psychiatric conditions (except mild substance use or tobacco/nicotine use) or high blood pressure at rest (above 140/90).
- You are not taking certain medications that affect serotonin or MAO inhibitors, or you can stop them for a while.
- You do not have a personal or family history of psychotic or bipolar I/II disorders.
- You are not currently having thoughts of suicide or harming others.
- You do not plan to move away within the next 6 months.
- You have not used psychedelics in the past 3 years, and you have had no more than 3 lifetime psychedelic experiences, no more than 3 lifetime ketamine or MDMA experiences, and never used 5-MeO-DMT or ibogaine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether psilocybin (a psychedelic medicine) can help people quit methamphetamine. You'll receive counseling before, during, and after the drug session, and your progress will be followed for several months.
This trial tests whether psilocybin (a psychedelic medicine) can help people who use methamphetamine and are living with HIV reduce or stop their meth use. You would receive psilocybin in a supervised setting and get counseling support to help you reach your goal of quitting.
This study tests whether a psychedelic drug called psilocybin, combined with talk therapy, can help people reduce or stop their use of stimulants like methamphetamine. It aims to see if this treatment is safe and helpful.
This study tests if psilocybin (a substance that can change how you think and feel) can help people reduce or stop using cannabis. You will receive support and be monitored closely throughout the trial.
This study tests whether a therapy that uses a psychedelic substance called psilocybin (a hallucinogen) can help people with severe alcohol problems. You would receive it in a supervised setting along with talk therapy, with the goal of helping you cut back or stop drinking.
This study tests whether a medicine called psilocybin, combined with talk therapy, can help people with hard-to-treat depression and a substance use problem. It aims to see if this treatment can improve mood and reduce substance use.
Hear when a new Methamphetamine Use Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.