Trastuzumab rezetecan with chemotherapy for recurrent ovarian cancer
Treatments studied
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial tests a new drug combination (trastuzumab rezetecan plus carboplatin) with or without bevacizumab, compared to standard chemotherapy, for ovarian cancer that has come back after platinum-based treatment. It aims to see if this combination works better than the usual options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have ovarian, fallopian tube, or primary peritoneal cancer (the most common type, not clear cell, low-grade serous, or mucinous).
- You have had 1 to 3 prior rounds of platinum-based chemo, and your cancer returned or worsened at least 6 months after the last one.
- You have already been treated with a PARP inhibitor (like olaparib or niraparib).
- Your tumor must show a certain marker called HER2, so you need to provide a tissue sample.
- You must have at least one tumor that can be measured on a scan, and you should be generally active (ECOG 0 or 1).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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