Comparing two pre-surgery treatments for esophageal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This study compares two standard approaches for treating esophageal cancer before surgery: chemotherapy combined with radiation versus chemotherapy combined with immunotherapy. The goal is to see which approach works better for shrinking tumors and improving outcomes in patients whose cancer is considered removable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older at the time of diagnosis.
- You have been diagnosed with esophageal squamous cell carcinoma (the most common type of esophageal cancer).
- The cancer is at a stage where it can be removed by surgery, but it may be at a local advanced stage (T3-4a or lymph node positive, without spread to other organs).
- You are generally healthy and able to perform normal daily activities (ECOG 0–1).
- You have not had any prior treatment for esophageal cancer (such as surgery, radiation, chemo, targeted therapy, or immunotherapy).
- You are not pregnant or breastfeeding, and you do not have known allergies to the study drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding two immunotherapy drugs to standard chemotherapy and radiation before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a certain type of esophageal cancer that can be removed with surgery.
This trial compares two treatment approaches for advanced esophageal squamous cell carcinoma (a type of cancer that starts in the lining of the food tube). One group receives chemotherapy combined with an immunotherapy drug before radiation; the other receives chemotherapy and radiation at the same time. The goal is to see which approach works better.
This study tests whether giving radiation therapy based on how well the tumor responds to initial chemoimmunotherapy can improve outcomes for people with a certain type of esophageal cancer. The goal is to find a more personalized treatment approach that may be more effective and possibly reduce side effects.
This trial tests a shorter course of radiation combined with two drugs (serplulimab and chemotherapy) before surgery for esophageal cancer. It aims to make tumors smaller and improve surgery outcomes.
This study tests whether giving additional immunotherapy after esophageal cancer surgery can help prevent the cancer from coming back. If you've already had chemotherapy and immunotherapy before surgery, this trial may offer a way to continue that benefit after your operation.
This trial is testing different treatment combinations before surgery for people with locally advanced esophageal squamous cell carcinoma. The goal is to find which approach works best based on specific biomarkers like PD-L1 levels.
Hear when a new Esophageal Squamous Cell Carcinoma (ESCC) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.