Chemotherapy and immunotherapy before surgery for esophageal cancer

Who can take part

• You are 18 years or older.
• You have been diagnosed with squamous cell carcinoma of the esophagus.
• Your cancer is at a stage where surgery is a treatment option.
• You have not had any prior cancer treatment for this condition.
• You are generally active and can care for yourself (ECOG 0-1).
• You are not pregnant or breastfeeding.
• You have not had other cancer in the last 5 years, except for certain skin cancers.
• Your doctors believe surgery is a good option for you.
• You do not have any other serious health conditions that would limit your life expectancy.
• You do not have allergies to the study drugs.
• You have not had immunotherapy or any of the study drugs before.
• You have not had surgery that would prevent you from receiving the study drugs.
• You are not hospitalized for more than 30 days in the past year (this is a proxy for overall health).
• You are not hospitalized for more than 14 days in the past year (this is a proxy for your performance status).
• You have not had any prior treatment for esophageal cancer.
• Your swallowing is not severely impaired.
• You have not had any weight loss greater than 10% in the past 3 months.
• You have not had a heart attack or stroke in the past 6 months.
• You do not have uncontrolled high blood pressure or diabetes.
• You are not enrolled in another clinical trial.
• You are not receiving any other investigational drugs.
• You are not pregnant or breastfeeding.
• You agree to use contraception during the study.
• You are willing and able to give informed consent.
• You are willing to comply with the study procedures.
• You have not had a blood transfusion in the past 2 weeks.
• You have not had surgery in the past 4 weeks.
• You have not had any other cancer treatment in the past 4 weeks.
• You have not had radiation to your chest or neck in the past 6 months.
• You have not had any autoimmune disease.
• You have not had an organ transplant.
• You have not had a weakened immune system.
• You have not had a live vaccine in the past 30 days.
• You have not had a severe infection in the past 2 weeks.
• You have not had a fracture in the past 6 months.
• You have not had a blood clot in the past 6 months.
• You have not had any bleeding problems.
• You have not had heart problems.
• You have not had lung problems.
• You have not had liver problems.
• You have not had kidney problems.
• You have not had thyroid problems.
• You have not had diabetes.
• You have not had a stroke.
• You have not had seizures.
• You have not had a mental illness.
• You have not had a drug or alcohol addiction.
• You have not been admitted to the hospital for more than 30 days in the past year.
• You have not been admitted to the hospital for more than 14 days in the past year.
• You have not had a solid organ transplant.
• You have not had a history of inflammatory bowel disease.
• You have not had a history of pulmonary fibrosis.
• You have not had a history of interstitial lung disease.
• You have not had a history of severe renal impairment.
• You have not had a history of severe hepatic impairment.
• You have not had a history of hepatitis B or C.
• You have not had a history of tuberculosis.
• You have not had a history of HIV.
• You have not had a history of a serious infection.
• You have not had a history of a major surgery within the past 4 weeks.
• You have not had a history of a severe trauma within the past 4 weeks.
• You have not had a history of a bleeding disorder.
• You have not had a history of a clotting disorder.
• You have not had a history of a stroke or TIA within the past 6 months.
• You have not had a history of a heart attack within the past 6 months.
• You have not had a history of heart failure.
• You have not had a history of an arrhythmia.
• You have not had a history of a heart valve problem.
• You have not had a history of a chest tube.
• You have not had a history of a lung biopsy.
• You have not had a history of a bronchoscopy.
• You have not had a history of an endoscopy.
• You have not had a history of a biopsy of the esophagus.
• You have not had a history of a stent in the esophagus.
• You have not had a history of radiation therapy to the chest.
• You have not had a history of chemotherapy.
• You have not had a history of immunotherapy.
• You have not had a history of targeted therapy.
• You have not had a history of surgery for esophageal cancer.
• You have not had a history of an allergy to the study drugs.
• You have not had a history of anaphylaxis.
• You have not had a history of a severe skin reaction.
• You have not had a history of a pulmonary embolism.
• You have not had a history of a deep vein thrombosis.
• You have not had a history of a pulmonary hemorrhage.
• You have not had a history of a gastrointestinal hemorrhage.
• You have not had a history of a perforation of the gastrointestinal tract.
• You have not had a history of a fistula.
• You have not had a history of an abscess.
• You have not had a history of a fistula.
• You have not had a history of a perforation.
• You have not had a history of a small bowel obstruction.
• You have not had a history of a large bowel obstruction.
• You have not had a history of a bowel perforation.
• You have not had a history of a bowel obstruction.
• You have not had a history of a perforated ulcer.
• You have not had a history of a gastric ulcer.
• You have not had a history of a duoden