Steroid diet mimicry for hormone therapy resistant breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a steroid drug combined with standard hormone therapy to see if it can make the cancer respond again. It is for people with hormone receptor positive, HER2 negative breast cancer that has spread and stopped responding to previous hormone treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your breast cancer must be hormone receptor positive (ER positive) and HER2 negative.
- Your cancer must have spread to other parts of the body.
- You must have already tried an aromatase inhibitor or fulvestrant (with or without a CDK4/6 inhibitor) and it stopped working, and your last treatment was not more than 8 weeks ago.
- If you are premenopausal, you must be on ovarian suppression (e.g., monthly injections or surgery to remove ovaries). If you are over 60 or postmenopausal, you qualify.
- You cannot be currently using steroid medications (even creams or inhalers) or have diabetes, significant osteoporosis, glaucoma, or serious heart conditions.
- You must have at least one tumor that can be measured on a CT or MRI scan, and be well enough (ECOG score 0-2).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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