Psilocybin therapy for demoralization in advanced cancer
Part of Cancer clinical trials.
This study tests whether psilocybin (a hallucinogen) combined with psychological support can help reduce feelings of hopelessness and loss of meaning in people with advanced cancer. It aims to see if this treatment can improve emotional well-being and quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You must have advanced cancer (Stage III, IV, or metastatic) or, if Stage II, your doctor confirms it is advanced or hard to treat.
- You need to have significant demoralization or distress as shown by a specific questionnaire.
- You must be able to attend at least 2 preparation sessions, 1 dosing session, and 2 integration sessions.
- You must speak and understand English well enough for therapy and questionnaires.
- If you can become pregnant, you must have a negative pregnancy test and use effective birth control.
- You need a responsible adult to stay with you for at least 12 hours after the dosing session.
- You cannot have active psychosis, mania, or serious suicidal thoughts or attempts recently.
- You cannot have unstable heart, liver, kidney, or blood sugar problems, or uncontrolled seizures.
- You must not be taking certain medications that would interfere with the study drug.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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