Clinical trials
Clear Aligner Appliance clinical trials
Below are recruiting clear aligner appliance clinical trials, each written for real people, not researchers. We’re tracking 7 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07215598Enrolling by invitation
Comparing Invisalign attachments on opposite sides of the mouth
This study tests how well Invisalign attachments work by comparing two different attachment designs placed on opposite sides of the mouth. It aims to find which type of attachment is more effective for moving teeth.
Baltimore, MarylandAges 18 years+ - NCT05684510Recruiting
Clear aligners vs braces for mild overbite in adults
This trial compares clear plastic aligners with fixed braces to improve mild overbite (Class II) in adults who have not had orthodontics before. It may help you understand which option works better for your bite and alignment while also checking fit and dental health needs.
Hama, Hama GovernorateAges 15–20 - NCT05573308Recruiting
Clear aligner study using remote monitoring and AI checks
This trial looks at clear braces (aligner) treatment for straightening teeth, using remote monitoring and computer-guided (AI) check-ins. It may help by making treatment progress easier to track and adjust.
Antioch, IllinoisAges 12–70 - NCT06934603Recruiting
Microplastic exposure from wearing clear aligners
This study looks at whether wearing clear aligners (like Invisalign) releases tiny plastic particles (microplastics) into your mouth. If you are already being treated with aligners, your participation could help understand any health effects.
Chapel Hill, North CarolinaAges 10–75 - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT07290790Recruiting
Trimline Aligner Accuracy Study
This trial tests SureSmile clear aligners to see how accurately they fix common bite problems like crowding, spacing, and overbite. You may be able to join if you need mild to moderate orthodontic treatment.
Fresno, CaliforniaAges 18 years+ - NCT07660809Recruiting
Comparing two clear aligner trim designs for comfort
This trial tests whether a different trim line on clear aligners feels more comfortable. You wear one design on your top teeth and the other on your bottom teeth, then answer a questionnaire about your experience.
Sibiu, Sibiu CountyAges 15 years+
Hear when a new Clear Aligner Appliance trial opens
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Common questions
- Are there clinical trials for clear aligner appliance?
- Yes. Clin2 currently lists 7 recruiting clear aligner appliance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clear aligner appliance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clear aligner appliance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.