Genitourinary Cancer clinical trials

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

Study genes in people who respond unusually to treatment

This study looks at stored tumor samples to understand why some people respond much better or much worse than expected. The goal is to learn what the tumor’s genes might be telling doctors about response to treatment.

Can Riluzole Help with Chemo Brain? A Pilot Study

This study tests if a medicine called riluzole (currently used for ALS) can help with 'chemo brain' – memory and thinking problems after cancer treatment. It is for people who feel their mental sharpness has declined after breast cancer therapy, certain chemotherapies, or brain radiation.

Atezolizumab for tumors that look sensitive on DNA/RNA testing

This Phase 2 study tests atezolizumab, an immunotherapy drug, in people with advanced, incurable solid tumors whose tumor DNA/RNA suggests they may respond. The goal is to see if the treatment works better for patients selected by these lab results.

Blood DNA test to see early treatment response in solid tumors

This study looks at circulating tumor DNA, which is tiny bits of DNA found in blood, to help assess how solid tumors are responding early. It uses blood samples from healthy adults who are willing to donate.

Natural history study of bladder and other genital cancers

This study follows people with urothelial cancer and certain rare genital (genitourinary) cancers over time to learn how these diseases progress. It may help researchers understand patterns of symptoms and outcomes, even if it is not a drug trial.

Testing cancer tissue to guide targeted treatment choices

This trial studies advanced solid tumors by using stored tumor samples to look for molecular clues. The goal is to help doctors better choose cancer treatments that may work for your specific tumor.

Riluzole to Prevent Chemo-Related Cognitive Problems

This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.

Imaging removed tissue during cancer surgery

This study tests a high-resolution PET-CT scanner that takes pictures of tissue removed during surgery to help doctors see if all the cancer has been removed. You might qualify if you are having surgery for a range of cancers including breast, prostate, thyroid, skin, gastrointestinal, or brain tumors.

Fecal transplant for immune-therapy diarrhea or bowel inflammation

This early-phase study tests whether stool/fecal microbiota transplant (a fecal transplant) can help people who develop significant diarrhea or colitis after immune-checkpoint therapy. It aims to reduce bowel inflammation and improve symptoms, while carefully checking for infections.

Understanding Vaginal Health Changes in Breast Cancer Survivors

This study examines vaginal dryness and discomfort—common side effects of breast cancer treatment—in women who've survived the disease. Researchers want to understand how often this happens and how much it affects daily life, which may help doctors better support survivors.

Adaptive Radiation Therapy for Genitourinary Cancers

This trial tests a more precise form of radiation therapy (adaptive radiotherapy) for people with urological cancers. It aims to adjust the radiation beam in real time to better target the tumor and protect healthy tissues, which may lead to fewer side effects.

Medication Use After Genitourinary Cancer Surgery

This study looks at the medications patients take after surgery for bladder, kidney, or prostate cancer. The goal is to understand how these medications are used and help improve recovery.

Study for menopause symptoms after breast cancer

This trial tests a treatment for menopause-like vaginal symptoms that can happen after breast cancer treatment. It aims to help survivors feel more comfortable.

Light plus job therapy for fatigue in genitourinary cancer

This trial tests whether light therapy and an occupational therapy fatigue program can reduce fatigue in people with certain urinary-system cancers who still have mild fatigue during treatment. It may help you feel more energized and manage day-to-day activity while cancer treatment is ongoing.

Surveys for coping and sexual health in bladder cancer survivors

This study asks women with bladder cancer to complete questionnaires about how they cope emotionally and about sexual health. It may help researchers understand what support survivors need and improve survivorship care.

Radiofrequency and exercise for pelvic floor issues after breast cancer

This trial tests whether radiofrequency therapy combined with exercise can help with pelvic floor problems like pain, urgency, or incontinence that some women have after breast cancer treatment.

Study of funded drugs for genitourinary cancers

This study looks at how well newer funded cancer drugs work for people with cancers of the urinary or reproductive systems, such as bladder, prostate, or kidney cancer. Researchers want to learn about real-world outcomes based on routine care in hospitals across Spain.

Vaginal laser therapy for breast cancer survivors with menopause symptoms

This trial tests whether a vaginal laser treatment can help breast cancer survivors who have menopause-like symptoms such as vaginal dryness or pain during sex. It is designed for women currently on hormone-blocking therapy.

Radiofrequency treatment for menopause symptoms in breast cancer survivors

This trial tests a non-surgical radiofrequency treatment, combined with pelvic floor exercises, to help with vaginal dryness and other menopause symptoms in breast cancer survivors. It may be an option if you are free of cancer and have bothersome vaginal dryness.

Shockwave therapy for penis recovery after prostate cancer surgery

This trial tests if low-intensity shockwaves can help men regain erectile function after robot-assisted prostate surgery. If you had nerve-sparing surgery and have good erections before treatment, this may help you recover faster.

Preventing blood clots in genitourinary cancer with rivaroxaban

This trial tests whether rivaroxaban, a blood thinner pill, can help prevent dangerous blood clots in people with certain genitourinary cancers who are starting cancer treatment. It may lower clot risk, but it also has bleeding-risk tradeoffs that the study will monitor closely.

Study of DCC-2812 for advanced genitourinary cancers

This trial tests an experimental pill called DCC-2812 for people with advanced kidney, bladder, or prostate cancer. The goal is to see if it is safe and if it might help shrink tumors or slow the cancer's growth.

Local therapy for progressing spots in genitourinary cancers

This trial explores whether treating only the new or growing spots of cancer (called oligoprogression) with local therapies like radiation or ablation can help you stay on your current systemic treatment longer. It is for people with prostate, bladder, or kidney cancer that has started to progress in a few places.