Riluzole to Prevent Chemo-Related Cognitive Problems
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism, Kidney & urinary, Lungs & breathing, Skin, Women’s health & pregnancy clinical trials.
This pilot study tests whether the drug riluzole can help prevent the thinking and memory problems (often called 'chemobrain') that some people experience during chemotherapy. If you are about to start a chemo regimen containing an anthracycline or platinum drug, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a cancer diagnosis and be scheduled for chemotherapy that includes an anthracycline or platinum drug (like doxorubicin or cisplatin).
- You must be at least 18 years old and have a life expectancy of more than 6 months.
- You agree to complete surveys and computer tests to measure thinking and memory (if you have vision problems or a condition like Parkinson's, you can still join as long as you can do the surveys with help).
- You cannot have a primary brain tumor or cancer that has spread to your brain.
- You cannot have liver problems (based on blood tests).
- You cannot be a current smoker, or be taking certain medications that could interact with riluzole (such as cannabis, certain cancer drugs, methotrexate, etc.), and if you are female and able to get pregnant, you must not be pregnant or planning to become pregnant during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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