Clinical trials
HIV Pre-exposure Prophylaxis clinical trials
Below are recruiting hiv pre-exposure prophylaxis clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06919419Recruiting
PrEP study for people in Dallas County Jail
This study tests a program to help people in jail get PrEP, a daily pill that prevents HIV. It aims to see if the program works well and is easy to use.
Dallas, TexasAges 18 years+ - NCT04331704RecruitingPhase 4
Alcohol and sexual health program for men at risk of HIV
This study tests an alcohol- and sexual-health program to help reduce HIV risk in men who recently had condomless sex and drink heavily. It may help you by offering structured support around drinking and HIV prevention (PrEP).
Gainesville, FloridaAges 18–30 - NCT06703060Recruiting
A trauma-informed approach to help Black women start PrEP
This study tests a program that helps Black women start PrEP (a daily pill to prevent HIV). It focuses on understanding and addressing past trauma to make it easier to take PrEP, and is designed for women who have not used PrEP before.
Baltimore, MarylandAges 18 years+ - NCT06576648Recruiting
HIV prevention study for young transgender women in Thailand
This study aims to reduce HIV stigma and improve PrEP use among young transgender women in Thailand. It is testing a new program to help those who are not already taking PrEP consistently.
BangkokAges 18–29 - NCT05165745Recruiting
Study of PrEP choices in women and transgender people
This study asks people who may use PrEP—an HIV prevention medicine—about their decision to start, not start, or stop PrEP. It aims to understand needs and barriers so PrEP can work better for cisgender women and transgender people who are considering it.
New York, New YorkAges 18 years+ - NCT06408142Recruiting
HIV testing and connection to care in South African ERs
This study tests a program that offers HIV testing and connects people to prevention or care right in the Emergency Department. It aims to make it easier for anyone visiting the ER to get the HIV services they need.
Cape Town, Western CapeAges 12 years+ - NCT06250504RecruitingPhase 3
HIV prevention study for young adults
This study tests a long-acting HIV prevention shot (Cabotegravir) or a vaginal ring (DapiRing) along with sexual health services for young people. It aims to find the best way to prevent HIV and support overall health.
Somkele, KwaZulu-NatalAges 15–30 - NCT06162897Recruiting
Case management for HIV or PrEP care support
This study tests whether pairing a case manager with people living with HIV or taking PrEP can help them stay in care and address financial or food problems.
Chicago, IllinoisAges 18 years+ - NCT06158126RecruitingPhase 4
Pregnancy and infant health outcomes study
This study follows pregnant women and their babies to see how well HIV prevention medicines work during pregnancy. It aims to help keep both mother and baby healthy.
LilongweAges 15–55 - NCT06056544Enrolling by invitation
HIV prevention support for Black men who have sex with men
This study tests a personalized care coordination program to help Black men who have sex with men stay on HIV prevention. It focuses on men who are new to or have stopped PrEP and want to reduce their HIV risk.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05804461Recruiting
PrEP support study for Latino gay and bisexual men in Puerto Rico
This study tests ways to help Latino men who have sex with men use PrEP, a medicine that helps prevent HIV. You may be invited if you are HIV-negative (or your status is unknown), are not currently on PrEP, and can read and write Spanish.
San JuanAges 21–99 - NCT05753683Recruiting
Online group talks to build social support for young women
This study tests whether online discussion groups can increase social support for young Black/African American women who have had recent substance use. It also specifically focuses on women who are HIV negative and not using PrEP, to support healthier choices and community connection.
Durham, North CarolinaAges 18–30 - NCT05669534RecruitingPhase 4
HIV prevention support for people starting PrEP
This study tests how to better support HIV prevention for people who inject drugs and are newly starting PrEP (medicine to prevent HIV). It focuses on people taking medication for opioid use disorder and who have mild thinking and memory problems, to help them stay safe and adhere to prevention.
New Haven, ConnecticutAges 18 years+ - NCT05492565Enrolling by invitation
Follow-up study for people on HIV prevention pills
This study follows adults who are at high risk of getting HIV while they take HIV prevention pills (PrEP). It aims to learn how well PrEP fits real-life use in people at risk and who may need extra care.
Seville, AndalusiaAges 18 years+ - NCT02437981Enrolling by invitation
PrEP for HIV prevention in high-risk adults in Thailand
This trial checks how well PrEP pills (TDF/FTC) prevent HIV in people who are at high risk and are HIV-negative. It may help you understand whether PrEP is a good prevention option for your situation.
Bangkok, PathumwanAges 18 years+ - NCT07397403RecruitingPhase 4
Doxycycline to prevent STIs in men who have sex with men
This trial tests whether taking a single dose of doxycycline after sex can prevent common sexually transmitted infections (STIs) like gonorrhea, chlamydia, and syphilis in men who have sex with men (MSM) in Bangkok.
Sathorn, BangkokAges 3 weeks–2 months - NCT07497594Recruiting
Twice-yearly shots to prevent HIV
This trial tests a new HIV prevention medicine called lenacapavir, given as a shot every six months. It's for young people at risk of HIV who haven't used PrEP before or have had gaps in their PrEP use.
Manaus, AmazonasAges 16–30
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Common questions
- Are there clinical trials for hiv pre-exposure prophylaxis?
- Yes. Clin2 currently lists 41 recruiting hiv pre-exposure prophylaxis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hiv pre-exposure prophylaxis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hiv pre-exposure prophylaxis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.