Clinical trials
HIV Pre-exposure Prophylaxis clinical trials
Below are recruiting hiv pre-exposure prophylaxis clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07772791Recruiting
Online study on digital tools for HIV prevention and treatment in Brazil
This study tests online programs to help people who are at higher risk for HIV get prevention or treatment. It aims to see if digital tools can improve access to and use of HIV medications.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07473778Recruiting
Study of Lenacapavir for HIV Prevention
This trial tests a new medication, lenacapavir, to see how well it works for preventing HIV. It is for people who want or need PrEP (a medicine to prevent HIV) and are interested in learning about different options.
Birmingham, AlabamaAges 18 years+ - NCT06919419Recruiting
PrEP study for people in Dallas County Jail
This study tests a program to help people in jail get PrEP, a daily pill that prevents HIV. It aims to see if the program works well and is easy to use.
Dallas, TexasAges 18 years+ - NCT06056544Enrolling by invitation
HIV prevention support for Black men who have sex with men
This study tests a personalized care coordination program to help Black men who have sex with men stay on HIV prevention. It focuses on men who are new to or have stopped PrEP and want to reduce their HIV risk.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05165745Recruiting
Study of PrEP choices in women and transgender people
This study asks people who may use PrEP—an HIV prevention medicine—about their decision to start, not start, or stop PrEP. It aims to understand needs and barriers so PrEP can work better for cisgender women and transgender people who are considering it.
New York, New YorkAges 18 years+ - NCT02437981Enrolling by invitation
PrEP for HIV prevention in high-risk adults in Thailand
This trial checks how well PrEP pills (TDF/FTC) prevent HIV in people who are at high risk and are HIV-negative. It may help you understand whether PrEP is a good prevention option for your situation.
Bangkok, PathumwanAges 18 years+ - NCT06162897Recruiting
Case management for HIV or PrEP care support
This study tests whether pairing a case manager with people living with HIV or taking PrEP can help them stay in care and address financial or food problems.
Chicago, IllinoisAges 18 years+ - NCT07614165Enrolling by invitation
HIV Prevention Decision Tool for Young Adults
This study tests a simple online tool to help young people decide whether PrEP (a daily pill that prevents HIV) might be right for them. The tool uses information from an at-home HIV test and is designed to make PrEP information easier to understand.
Ann Arbor, MichiganAges 18–39 - NCT05804461Recruiting
PrEP support study for Latino gay and bisexual men in Puerto Rico
This study tests ways to help Latino men who have sex with men use PrEP, a medicine that helps prevent HIV. You may be invited if you are HIV-negative (or your status is unknown), are not currently on PrEP, and can read and write Spanish.
San JuanAges 21–99 - NCT07467018Recruiting
Mobile van study of a long-acting HIV prevention shot
This study tests if giving a long-acting HIV prevention shot (lenacapavir) from a mobile medical van can reach people at risk for HIV in Los Angeles County. You may be able to join if you are HIV negative, at risk for HIV, and are willing to try a shot instead of a daily pill.
Santa Monica, CaliforniaAges 18 years+ - NCT06046079Recruiting
HIV Prevention Service Use Study in Washington DC
This study looks at how people in the Washington, DC area use HIV prevention services. It focuses on those who are HIV-negative and either new to PrEP, taking daily PrEP pills, or getting long-acting injectable PrEP.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07221747Recruiting
PERSIST trial: PrEP injections for HIV prevention
This study gives long-acting cabotegravir injections (a shot every 2 months) to people at high risk of HIV. It aims to see if this new prevention method works well in real-world settings.
LilongweAges 15–110 - NCT07218211RecruitingPhase 4
Injectable PrEP study for Latine transgender women and gay men
This study offers a long-acting injectable form of PrEP (lenacapavir) to prevent HIV in Latine transgender women and gay men in the South. It aims to make HIV prevention easier by providing a shot instead of a daily pill.
Durham, North CarolinaAges 18 years+ - NCT06576648Recruiting
HIV prevention study for young transgender women in Thailand
This study aims to reduce HIV stigma and improve PrEP use among young transgender women in Thailand. It is testing a new program to help those who are not already taking PrEP consistently.
BangkokAges 18–29 - NCT06703060Recruiting
A trauma-informed approach to help Black women start PrEP
This study tests a program that helps Black women start PrEP (a daily pill to prevent HIV). It focuses on understanding and addressing past trauma to make it easier to take PrEP, and is designed for women who have not used PrEP before.
Baltimore, MarylandAges 18 years+ - NCT06158126RecruitingPhase 4
Pregnancy and infant health outcomes study
This study follows pregnant women and their babies to see how well HIV prevention medicines work during pregnancy. It aims to help keep both mother and baby healthy.
LilongweAges 15–55 - NCT07683117Recruiting
PEP/PrEP through pharmacist prescribing (PEPPI)
This study looks at how well pharmacists can provide PEP and PrEP (HIV prevention pills) using a special software called PEPPI. It aims to make it easier and faster for people to get these medicines.
Del Mar, CaliforniaAges 18 years+ - NCT07579754Recruiting
Understanding Women's HIV Prevention Medicine Choices in Malawi
This study aims to understand why some women in Malawi stopped taking PrEP (a medicine that prevents HIV) and what could help them stay on treatment. Researchers will contact women who started PrEP but missed their appointments to learn about their experiences and barriers.
BlantyreAges 18–110 - NCT07462611Recruiting
Starting PrEP for HIV prevention in the emergency department
This study is testing whether starting PrEP (daily pills to prevent HIV) right away in the emergency department helps people at high risk for HIV. It aims to make it easier to start protection before you leave the hospital.
Dallas, TexasAges 18 years+ - NCT04331704RecruitingPhase 4
Alcohol and sexual health program for men at risk of HIV
This study tests an alcohol- and sexual-health program to help reduce HIV risk in men who recently had condomless sex and drink heavily. It may help you by offering structured support around drinking and HIV prevention (PrEP).
Gainesville, FloridaAges 18–30 - NCT04430257Recruiting
PrEP for people at higher risk of HIV
This study checks whether taking HIV prevention medicine called PrEP can help protect people who are not living with HIV but have recent risk of HIV exposure. You may qualify if you have ongoing risk and are not already taking PrEP.
Cambridge, MassachusettsAges 18 years+ - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT05326061Recruiting
Study for people at high risk of getting HIV
This registry study looks at people who are HIV-negative but at high risk of getting HIV, to better understand risk and care needs. If you qualify, you may be asked to share health and behavior information to help guide future prevention efforts.
ViennaAges 18–100 - NCT05515770RecruitingPhase 3
Injectable PrEP shot for HIV prevention in higher-risk adults
This Phase 3 study tests whether an injectable HIV prevention medicine (cabotegravir) given before exposure can help prevent HIV in people at higher risk. You may join if you are HIV-negative and meet specific sexual health, medication, and health-testing requirements.
Rio de JaneiroAges 18–30
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HIV Pre-exposure Prophylaxis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for hiv pre-exposure prophylaxis?
- Yes. Clin2 currently lists 41 recruiting hiv pre-exposure prophylaxis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hiv pre-exposure prophylaxis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hiv pre-exposure prophylaxis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.