Clinical trials
PrEP clinical trials
Below are recruiting prep clinical trials, each written for real people, not researchers. We’re tracking 82 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07462611Recruiting
Starting PrEP for HIV prevention in the emergency department
This study is testing whether starting PrEP (daily pills to prevent HIV) right away in the emergency department helps people at high risk for HIV. It aims to make it easier to start protection before you leave the hospital.
Dallas, TexasAges 18 years+ - NCT05905640Recruiting
PrEP clinic support study for Kenya health workers and policy makers
This trial tests a “one-stop” support pathway meant to make it easier for PrEP clinics in Kenya to deliver PrEP care. It involves interviews with people using PrEP services and with healthcare and policy leaders who help run or guide PrEP delivery.
KisumuAges 15 years+ - NCT06868641Recruiting
Study for people stopping long-acting injectable PrEP
This study follows people who are stopping long-acting injectable PrEP (cabotegravir or lenacapavir). It checks how long the drug stays in your body and helps make sure you stay protected during that time. You'll do monthly video visits, mail in blood samples, and fill out short surveys.
New York, New YorkAges 18 years+ - NCT06743204Recruiting
Testing for sexually transmitted infections in women at risk for HIV
This study tests if combining sexually transmitted infection (STI) testing with HIV prevention medication (PrEP) helps control the HIV epidemic. It is for sexually active women aged 15-39 who live in Rakai and recently participated in a community health survey.
KalisizoAges 15–39 - NCT06724965Recruiting
Trauma treatment and PrEP support for transgender and nonbinary adults
This study combines a proven trauma treatment (STAIR) with peer-led PrEP navigation to help transgender and nonbinary people cope with stress and stay HIV-free. It aims to improve mental health and increase PrEP use.
Los Angeles, CaliforniaAges 18 years+ - NCT06566430Recruiting
PrEP My Way: Helping young women stay on PrEP
This study tests whether a program called 'PrEP My Way' can help young women in Kenya stick with taking PrEP pills to prevent HIV. It's designed for women ages 16–24 who are just starting PrEP in Kisumu County.
KisumuAges 16–24 - NCT06158126RecruitingPhase 4
Pregnancy and infant health outcomes study
This study follows pregnant women and their babies to see how well HIV prevention medicines work during pregnancy. It aims to help keep both mother and baby healthy.
LilongweAges 15–55 - NCT05968755Recruiting
Chatbot to help black men in the south start PrEP
This study tests a chatbot that gives you information and support to help you start or stay on PrEP, a daily pill that prevents HIV. It's for Black men in the Southern U.S. who might be at higher risk.
Miami, FloridaAges 18 years+ - NCT07614165Enrolling by invitation
HIV Prevention Decision Tool for Young Adults
This study tests a simple online tool to help young people decide whether PrEP (a daily pill that prevents HIV) might be right for them. The tool uses information from an at-home HIV test and is designed to make PrEP information easier to understand.
Ann Arbor, MichiganAges 18–39 - NCT07579754Recruiting
Understanding Women's HIV Prevention Medicine Choices in Malawi
This study aims to understand why some women in Malawi stopped taking PrEP (a medicine that prevents HIV) and what could help them stay on treatment. Researchers will contact women who started PrEP but missed their appointments to learn about their experiences and barriers.
BlantyreAges 18–110 - NCT07584122Recruiting
Increasing HIV Prevention Access in Rio de Janeiro
This study helps people at higher risk of HIV get access to PrEP, a daily medication that prevents HIV infection. The program focuses on underserved communities in Rio de Janeiro and aims to make PrEP easier to access and use.
Nova Iguaçu, Rio de JaneiroAges 15 years+ - NCT07516548Recruiting
Long-acting HIV prevention and birth control study
This research studies how two types of long-acting birth control (a shot called cabotegravir and an implant) work in your body after pregnancy, and how they interact with HIV prevention or treatment. The study helps doctors understand the best doses and timing for women like you.
Bontleng, GaboroneAges 18 years+ - NCT06807736Recruiting
Choosing injectable PrEP for HIV prevention in Cape Town
This study offers three ways to prevent HIV: a shot every two months (injectable PrEP), daily pills, or a vaginal ring. Researchers in Cape Town will help you choose the option that fits your life best.
Cape Town, Western ProvinceAges 15 years+ - NCT07438041Recruiting
Helping young people start prep for hiv prevention
This study helps young people who are at risk for HIV get on PrEP—a daily pill or shot that prevents HIV. It tests different ways to help you start and stay on PrEP, with care available at clinics or in your community.
San Francisco, CaliforniaAges 13–24 - NCT07231640Recruiting
Improving PrEP care for clinic staff
This study looks at ways to improve PrEP (pre-exposure prophylaxis) care by helping clinic staff track and support patients better. It's for healthcare workers, managers, and data staff at certain PrEP clinics.
Birmingham, AlabamaAges 18 years+ - NCT07076043RecruitingPhase 4
HIV prevention for young women getting reproductive health care
This study offers different forms of HIV prevention medicine (PrEP) to young women ages 18–30 who are visiting clinics for reproductive health services like family planning or postnatal care. It aims to see which delivery method works best for you.
Thika, Kiambu CountyAges 18–30 - NCT06853314Recruiting
PrEP for women with past legal or child welfare involvement
This trial tests a program to help women who have had contact with the criminal legal system or child protective services get and stay on PrEP (a daily pill that prevents HIV). The study also looks at how to support women who have experienced intimate partner violence or risky drinking.
New York, New YorkAges 18 years+ - NCT06666309Enrolling by invitation
Study on HIV prevention for people who inject drugs
This study tests different ways to help people who inject drugs stay on PrEP, a daily pill that prevents HIV. It's for people who are HIV-negative and have recently injected drugs.
Barbourville, KentuckyAges 18 years+ - NCT06638892Recruiting
PrEP study for Black cisgender women
This study tests ways to help Black cisgender women take PrEP, a daily pill that prevents HIV infection. It focuses on making PrEP work for you.
Durham, North CarolinaAges 18 years+ - NCT06334341Enrolling by invitation
Study to improve PrEP use in primary care
This trial tests ways to help primary care providers and their patients start using PrEP, a daily pill that prevents HIV. It may be right for you if you are interested in HIV prevention.
Detroit, MichiganAges 18 years+ - NCT07472127Recruiting
Emotional preparedness training for new nurses
This study tests a program to help new nurse residents feel more emotionally prepared for their jobs. It may improve confidence and readiness in the workplace.
Orlando, FloridaAges Any age - NCT06558825Recruiting
PrEP support for women with trauma history
This study tests a program to help women who have experienced trauma and are at risk for HIV start and stay on PrEP (a daily pill that prevents HIV). It looks at whether mental health treatment can boost PrEP use.
Houston, TexasAges 18 years+ - NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT07510048Recruiting
PrEP choice study for young men at higher risk for HIV
This study compares different ways to help young men learn about and choose PrEP, a medicine that prevents HIV. It aims to see which approach works best for starting and staying on PrEP.
San Francisco, CaliforniaAges 13–24
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PrEP trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for prep?
- Yes. Clin2 currently lists 82 recruiting prep studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prep trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prep trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.