Clinical trials
PrEP clinical trials
Below are recruiting prep clinical trials, each written for real people, not researchers. We’re tracking 82 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06656676Recruiting
WePrEP: HIV prevention tool for transgender women
This study is creating a decision-making tool to help transgender women choose the right PrEP (HIV prevention pill) for them. It is looking for transgender women in Denver who are HIV-negative and interested in learning more about PrEP, as well as healthcare providers who help transgender women decide about PrEP.
Sheridan, ColoradoAges 18–65 - NCT07292584Recruiting
Digital toolkit to help women start PrEP
This trial tests a digital toolkit to help women start taking PrEP, a medication that prevents HIV. It looks at whether the toolkit makes it easier for women to take PrEP consistently.
Birmingham, AlabamaAges 18 years+ - NCT07221747Recruiting
PERSIST trial: PrEP injections for HIV prevention
This study gives long-acting cabotegravir injections (a shot every 2 months) to people at high risk of HIV. It aims to see if this new prevention method works well in real-world settings.
LilongweAges 15–110 - NCT07218211RecruitingPhase 4
Injectable PrEP study for Latine transgender women and gay men
This study offers a long-acting injectable form of PrEP (lenacapavir) to prevent HIV in Latine transgender women and gay men in the South. It aims to make HIV prevention easier by providing a shot instead of a daily pill.
Durham, North CarolinaAges 18 years+ - NCT07194902Recruiting
HIV self-testing for partners of new and expecting mothers
This study offers HIV self-testing kits to the partners of pregnant women and new mothers who are HIV-negative. It aims to make testing easier and more accessible for partners whose HIV status is unknown.
Durban, KwaZulu-NatalAges 18 years+ - NCT07186244Recruiting
HIV Prevention Study for People Starting or Taking PrEP
This study is for people who are HIV-negative and want to take PrEP (a daily pill that prevents HIV). It will help researchers learn more about how to best support people taking PrEP in real-world settings.
Chieti, AbruzzoAges 18 years+ - NCT07160075RecruitingPhase 4
HIV prevention with PrEP for people on opioid therapy
This trial tests if daily PrEP medication can help prevent HIV in people receiving opioid replacement therapy. You must be HIV-negative and regularly attend your opioid treatment program to join.
Calgary, AlbertaAges 16 years+ - NCT07089966Recruiting
PrEP delivery in family planning clinics
This trial tests a program where HIV testing counselors help family planning patients learn about and get PrEP, a daily pill that prevents HIV. It aims to make PrEP easier to access in clinics you may already visit.
KisumuAges 15 years+ - NCT07053527Enrolling by invitation
Welcome to PrEP School: Peer-led HIV Prevention Study
This study tests if peer educators can help more students start PrEP, a daily pill that prevents HIV. If you are a student at one of the four listed colleges, you may be able to join.
Atlanta, GeorgiaAges 18–26 - NCT07002866Recruiting
PrEP access and adherence study for young women in Uganda
This study tests a program to help adolescent girls and young women at high risk of HIV take PrEP consistently. It aims to improve access and adherence to PrEP, a daily pill that prevents HIV.
St Louis, MissouriAges 15–24 - NCT06927856Recruiting
Test-to-PrEP study: connecting with friends about HIV testing and PrEP
This study looks at whether people already taking PrEP (a daily pill to prevent HIV) can share HIV self-test kits and PrEP information with friends or others in their social network. It may help you if you are on PrEP and want to help others learn about HIV prevention.
Miami, FloridaAges 18 years+ - NCT06919419Recruiting
PrEP study for people in Dallas County Jail
This study tests a program to help people in jail get PrEP, a daily pill that prevents HIV. It aims to see if the program works well and is easy to use.
Dallas, TexasAges 18 years+ - NCT06919614RecruitingPhase 3
Testing STIs to Improve PrEP Use in Pregnancy
This trial tests whether STI testing during pregnancy helps more women start and stay on PrEP (a daily pill that prevents HIV). If you join, you'll help find better ways to protect both mother and baby from HIV.
GaboroneAges Any age - NCT06845774Enrolling by invitation
PrEP support via telehealth for people who inject drugs
This trial tests whether telehealth support can help people who inject drugs start and stay on PrEP (HIV prevention medicine). You will join several sessions and follow-up visits to see if this approach works better than standard care.
Lexington, KentuckyAges 18–99 - NCT06692673RecruitingPhase 1/Phase 2
Linaclotide for Colonoscopy Bowel Preparation
This trial tests if a medication called linaclotide (a pill that helps with constipation) can improve the bowel-cleaning process before a colonoscopy. It may make the preparation easier and more effective.
Gainesville, FloridaAges 18–65 - NCT06684613RecruitingPhase 2
PrEP decision-making counseling for women in sexual health clinics
This study tests a counseling program to help women decide whether to use PrEP (a daily pill that prevents HIV). It aims to make PrEP choices easier and more informed in sexual and reproductive health clinics.
New Haven, ConnecticutAges 18 years+ - NCT06501781Recruiting
PUSH: Helping People with HIV and Substance Use
This study tests if a program that encourages positive activities (behavioral activation) can help people with HIV or on PrEP who also use substances improve their health. It focuses on those receiving long-acting injectable medications for HIV prevention or treatment.
Washington D.C., District of ColumbiaAges 18–88 - NCT06141408Recruiting
PrEP for Black men in Prince George's County
This study looks at whether a new program can help Black men in Prince George's County, Maryland, start or stay on PrEP, a daily pill that prevents HIV. If you're HIV-negative and at risk, this could be a way to protect your health.
Fairfax, VirginiaAges 18 years+ - NCT04945317Enrolling by invitation
ROSE to improve lung cancer marker testing with a breathing scope
This trial studies a quick scan method (called ROSE) during bronchoscopy to help doctors get the right lung cancer tissue and test cancer markers more accurately. If you are being evaluated for non-small cell lung cancer, the study may improve how well and how fast your samples can be tested.
Chicago, IllinoisAges 18 years+ - NCT02437981Enrolling by invitation
PrEP for HIV prevention in high-risk adults in Thailand
This trial checks how well PrEP pills (TDF/FTC) prevent HIV in people who are at high risk and are HIV-negative. It may help you understand whether PrEP is a good prevention option for your situation.
Bangkok, PathumwanAges 18 years+ - NCT04855773Recruiting
Mobile text-message support to help people stay on PrEP
This trial tests whether phone-based (iPhone/Android) text-message support can improve how consistently people use PrEP, an HIV prevention medicine. It may help you stay on track with refills and clinic visits, especially if you’re at higher risk of stopping PrEP.
San Francisco, CaliforniaAges 15 years+ - NCT06005298Recruiting
Testing SBIRT to help with PrEP and alcohol use
This study looks at whether talking about alcohol use can help people stick with their PrEP routine. It tests a simple program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) to support your health and HIV prevention.
Louisville, KentuckyAges 18–85 - NCT07533240Recruiting
Tooth Wear Treatment Effects on Bite and Jaw
This study looks at how a specific tooth-restoration treatment (called the One-Step No-Prep protocol) affects your bite alignment and jaw joint over time. Researchers want to understand if this treatment helps improve how your teeth fit together.
LiègeAges 18 years+ - NCT07509827Recruiting
App-based program to help prevent HIV and reduce stigma
This study tests a mobile health program to help young transgender women prevent HIV and cope with stigma. Participants use an app and are not yet taking PrEP daily or have trouble sticking with it.
Bangkok, BangkapiAges 18–29
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Common questions
- Are there clinical trials for prep?
- Yes. Clin2 currently lists 82 recruiting prep studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prep trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prep trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.