Clinical trials
PrEP clinical trials
Below are recruiting prep clinical trials, each written for real people, not researchers. We’re tracking 79 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07218211RecruitingPhase 4
Injectable PrEP study for Latine transgender women and gay men
This study offers a long-acting injectable form of PrEP (lenacapavir) to prevent HIV in Latine transgender women and gay men in the South. It aims to make HIV prevention easier by providing a shot instead of a daily pill.
Durham, North CarolinaAges 18 years+ - NCT06845774Enrolling by invitation
PrEP support via telehealth for people who inject drugs
This trial tests whether telehealth support can help people who inject drugs start and stay on PrEP (HIV prevention medicine). You will join several sessions and follow-up visits to see if this approach works better than standard care.
Lexington, KentuckyAges 18–99 - NCT07053527Enrolling by invitation
Welcome to PrEP School: Peer-led HIV Prevention Study
This study tests if peer educators can help more students start PrEP, a daily pill that prevents HIV. If you are a student at one of the four listed colleges, you may be able to join.
Atlanta, GeorgiaAges 18–26 - NCT07002866Recruiting
PrEP access and adherence study for young women in Uganda
This study tests a program to help adolescent girls and young women at high risk of HIV take PrEP consistently. It aims to improve access and adherence to PrEP, a daily pill that prevents HIV.
St Louis, MissouriAges 15–24 - NCT07194902Recruiting
HIV self-testing for partners of new and expecting mothers
This study offers HIV self-testing kits to the partners of pregnant women and new mothers who are HIV-negative. It aims to make testing easier and more accessible for partners whose HIV status is unknown.
Durban, KwaZulu-NatalAges 18 years+ - NCT05689281Recruiting
PrEP support for trans women in New Orleans
This study aims to help more trans women (and other women who were assigned male at birth) use or restart PrEP, a medication that helps prevent HIV. You may be eligible if you are HIV-uninfected, live in the New Orleans area, and can do regular follow-up visits.
New Orleans, LouisianaAges 18 years+ - NCT06141408Recruiting
PrEP for Black men in Prince George's County
This study looks at whether a new program can help Black men in Prince George's County, Maryland, start or stay on PrEP, a daily pill that prevents HIV. If you're HIV-negative and at risk, this could be a way to protect your health.
Fairfax, VirginiaAges 18 years+ - NCT06158607Recruiting
PrEP adherence help for women with substance use
This study tests a program to help Black and Hispanic women with substance use disorders take PrEP consistently to prevent HIV. The goal is to see if talking with a health coach can improve PrEP use and reduce HIV risk.
Houston, TexasAges 18–60 - NCT06501781Recruiting
PUSH: Helping People with HIV and Substance Use
This study tests if a program that encourages positive activities (behavioral activation) can help people with HIV or on PrEP who also use substances improve their health. It focuses on those receiving long-acting injectable medications for HIV prevention or treatment.
Washington D.C., District of ColumbiaAges 18–88 - NCT06558825Recruiting
PrEP support for women with trauma history
This study tests a program to help women who have experienced trauma and are at risk for HIV start and stay on PrEP (a daily pill that prevents HIV). It looks at whether mental health treatment can boost PrEP use.
Houston, TexasAges 18 years+ - NCT06919614RecruitingPhase 3
Testing STIs to Improve PrEP Use in Pregnancy
This trial tests whether STI testing during pregnancy helps more women start and stay on PrEP (a daily pill that prevents HIV). If you join, you'll help find better ways to protect both mother and baby from HIV.
GaboroneAges Any age - NCT06927856Recruiting
Test-to-PrEP study: connecting with friends about HIV testing and PrEP
This study looks at whether people already taking PrEP (a daily pill to prevent HIV) can share HIV self-test kits and PrEP information with friends or others in their social network. It may help you if you are on PrEP and want to help others learn about HIV prevention.
Miami, FloridaAges 18 years+ - NCT07089966Recruiting
PrEP delivery in family planning clinics
This trial tests a program where HIV testing counselors help family planning patients learn about and get PrEP, a daily pill that prevents HIV. It aims to make PrEP easier to access in clinics you may already visit.
KisumuAges 15 years+ - NCT07160075RecruitingPhase 4
HIV prevention with PrEP for people on opioid therapy
This trial tests if daily PrEP medication can help prevent HIV in people receiving opioid replacement therapy. You must be HIV-negative and regularly attend your opioid treatment program to join.
Calgary, AlbertaAges 16 years+ - NCT07186244Recruiting
HIV Prevention Study for People Starting or Taking PrEP
This study is for people who are HIV-negative and want to take PrEP (a daily pill that prevents HIV). It will help researchers learn more about how to best support people taking PrEP in real-world settings.
Chieti, AbruzzoAges 18 years+ - NCT04945317Enrolling by invitation
ROSE to improve lung cancer marker testing with a breathing scope
This trial studies a quick scan method (called ROSE) during bronchoscopy to help doctors get the right lung cancer tissue and test cancer markers more accurately. If you are being evaluated for non-small cell lung cancer, the study may improve how well and how fast your samples can be tested.
Chicago, IllinoisAges 18 years+ - NCT07246057Recruiting
Improving PrEP access with telehealth and community partners
This study looks at how telehealth can make PrEP (medication that helps prevent HIV) easier to get, by partnering with community organizations in Philadelphia. Researchers want to interview or survey clients and staff to understand what works and what could be improved.
Philadelphia, PennsylvaniaAges 16 years+ - NCT05736614Recruiting
Helping men who have sex with men take PrEP consistently
This trial tests ways to improve how well people take PrEP (a medicine that helps prevent HIV) consistently. It may help you if you’re at higher risk and are not currently on PrEP, especially around starting and staying on it.
Los Angeles, CaliforniaAges 18 years+ - NCT06930508Recruiting
Bringing HIV prevention meds to a family planning clinic
This study looks at offering HIV prevention medicines (PrEP) to patients visiting a family planning clinic. It aims to make it easier for people to access this care alongside their regular visit.
Providence, Rhode IslandAges 16 years+ - NCT06880224Recruiting
HIV prevention and treatment for Nigerian youth aged 15-24
This study tests better ways to find and treat HIV in young people (ages 15-24) in Nigeria. It offers either HIV prevention medicine (PrEP) if you are HIV-negative, or HIV treatment if you are newly diagnosed with HIV.
Uyo, Akwa Ibom StateAges 15–24 - NCT06785376Recruiting
HIV testing and PrEP for Black men who have sex with men
This study tests whether a program combining counseling and support can help more Black men in New York City get tested for HIV and start using PrEP or PEP (medicines that prevent HIV). If you are a Black man who has sex with men and are not living with HIV, this trial may be a good fit.
New York, New YorkAges 18–65 - NCT07509827Recruiting
App-based program to help prevent HIV and reduce stigma
This study tests a mobile health program to help young transgender women prevent HIV and cope with stigma. Participants use an app and are not yet taking PrEP daily or have trouble sticking with it.
Bangkok, BangkapiAges 18–29 - NCT06964373Recruiting
Cervical ripening balloons for same-day abortion preparation
This study tests using a small balloon to prepare the cervix for a same-day abortion procedure between 18 and almost 20 weeks of pregnancy. It may help people who want the procedure done without needing to stay overnight.
Albuquerque, New MexicoAges 18 years+ - NCT05804461Recruiting
PrEP support study for Latino gay and bisexual men in Puerto Rico
This study tests ways to help Latino men who have sex with men use PrEP, a medicine that helps prevent HIV. You may be invited if you are HIV-negative (or your status is unknown), are not currently on PrEP, and can read and write Spanish.
San JuanAges 21–99
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Common questions
- Are there clinical trials for prep?
- Yes. Clin2 currently lists 79 recruiting prep studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prep trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prep trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.