Clinical trials · California
Schizophrenia clinical trials in California
We’re tracking 50 recruiting schizophrenia studies with a site in California — including Early Phase 1, Phase 1, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07459647RecruitingPhase 2
Long-term study of ML-007C-MA for schizophrenia
This trial tests a new drug, ML-007C-MA, for adults with schizophrenia who may benefit from ongoing treatment. It aims to see how safe and effective the drug is over a longer period.
Bellflower, CaliforniaAges 18–65 - NCT03094429RecruitingPhase 2/Phase 3
Testing NaBen add-on to clozapine for tough schizophrenia symptoms
This trial tests whether adding NaBen (a supplement-like medicine) to clozapine can improve “residual” symptoms in adults with difficult-to-treat schizophrenia. The study also checks safety and the best dose, using a placebo (inactive pill) for comparison.
Pasadena, CaliforniaAges 18–55 - NCT07734493RecruitingPhase 1
Study of a new drug for acute schizophrenia symptoms
This trial tests an experimental medicine, LTX-001, for people with schizophrenia who are currently having a sudden worsening of symptoms. It aims to see if the drug can help reduce these acute symptoms.
Los Alamitos, CaliforniaAges 18–55 - NCT07686263RecruitingPhase 3
Testing a new drug to prevent schizophrenia relapse
This trial tests whether a new oral medication, KarXT, can help prevent a return of schizophrenia symptoms in people who have been stable on treatment. If you've had a hospital stay in the past year and still have some symptoms, you may be able to join.
Anaheim, CaliforniaAges 18–65 - NCT07615426RecruitingPhase 1
Testing aticaprant with antipsychotic medication for schizophrenia
This study tests whether a new medication called aticaprant is safe and well-tolerated when added to your current antipsychotic medication for schizophrenia. The goal is to see if it could help improve symptoms without causing serious side effects.
Garden Grove, CaliforniaAges 18–55 - NCT07565428RecruitingPhase 3
Study of roluperidone for negative symptoms of schizophrenia
This trial tests a new medicine called roluperidone for people with schizophrenia who have ongoing negative symptoms (like low motivation or social withdrawal) but stable positive symptoms (like hallucinations). It aims to see if the drug helps with these symptoms and if it can reduce the chance of relapse compared to other medications.
Culver City, CaliforniaAges 18–55 - NCT05184335RecruitingPhase 3
Brilaroxazine for adults with schizophrenia
This study tests whether brilaroxazine works and is safe for people with schizophrenia. It mainly aims to help people whose symptoms are still present despite prior treatment, while excluding those with certain other diagnoses or substance/drug issues.
Garden Grove, CaliforniaAges 18–65 - NCT07467993RecruitingPhase 2
Testing GXV813 for hospitalized adults with schizophrenia
This trial tests a new drug, GXV813, to see if it helps reduce symptoms in people with schizophrenia who are currently hospitalized due to a sudden worsening of their condition. It compares the drug's safety and effect against a placebo over several weeks.
Pico Rivera, CaliforniaAges 18–65 - NCT07410507RecruitingPhase 2
Study of Brenipatide for adults with schizophrenia
This trial tests an investigational drug called brenipatide for people with schizophrenia who are already on a stable medication regimen. The goal is to see if adding this drug helps reduce relapses.
Bellflower, CaliforniaAges 18–55 - NCT07363577RecruitingPhase 3
Testing LB-102 for adults with acute schizophrenia
This trial tests a new medication called LB-102 for people with acute (sudden worsening of) schizophrenia. It aims to see if the drug helps reduce symptoms like hallucinations or disorganized thinking.
Culver City, CaliforniaAges 18–65 - NCT07344948RecruitingEarly Phase 1
Testing NTX-253 in healthy people and those with stable schizophrenia
This trial is testing a new medicine, NTX-253, to see how safe it is and how the body processes it. It is for healthy adults and adults with schizophrenia whose symptoms are stable on their current treatment.
Los Alamitos, CaliforniaAges 18–55 - NCT07288567RecruitingPhase 3
KarXT for teens with schizophrenia
This trial tests if a new medicine, KarXT, can safely and effectively treat schizophrenia in adolescents. It may help teenagers who have active symptoms like hallucinations or disorganized thinking.
Anaheim, CaliforniaAges 13–17 - NCT07227818RecruitingPhase 3
Testing NBI-1117568 to prevent schizophrenia relapse
This trial tests a new medicine, NBI-1117568, to see if it can help prevent a relapse of schizophrenia symptoms. It is for adults who have been stable on other antipsychotics and want to avoid returning to the hospital for a psychiatric stay.
La Habra, CaliforniaAges 18–65 - NCT07184619RecruitingPhase 3
Evenamide for hard-to-treat schizophrenia (add-on study)
This trial tests a new medication, evenamide, added to your current antipsychotic treatment. It looks to see if it can help people whose schizophrenia has not responded well to standard therapies.
Los Angeles, CaliforniaAges 18 years+ - NCT07191483RecruitingPhase 2
Study of KYN-5356 for cognitive problems in schizophrenia
This trial tests an investigational drug, KYN-5356, to see if it can improve thinking and memory problems in adults with schizophrenia. You may join if your schizophrenia is stable and you take only one antipsychotic medication.
Cerritos, CaliforniaAges 18–55 - NCT07177261Recruiting
Brain synchrony study for schizophrenia
This study looks at how brain activity syncs between people with schizophrenia and others. It aims to understand social interaction differences—potentially leading to better treatments.
Los Angeles, CaliforniaAges 18–65 - NCT07145918RecruitingPhase 2
Study of an oral schizophrenia drug for adults
This trial tests an experimental oral drug (emraclidine) to see if it helps symptoms of schizophrenia and how it moves through the body. It looks at two groups of participants: those with stable symptoms and those having an acute flare-up.
Glendale, CaliforniaAges 18–65 - NCT07114874RecruitingPhase 3
A long-term study of a new drug for schizophrenia
This study tests a new medicine called NBI-1117568 for adults with schizophrenia over a longer period of time. Participants will stop their current antipsychotics and take this new drug to see how well it works and how safe it is.
Cerritos, CaliforniaAges 18–65 - NCT07105098RecruitingPhase 3
Study of a new drug for schizophrenia in hospitalized adults
This study tests an experimental drug (NBI-1117568) for people with schizophrenia who are currently in the hospital due to worsening symptoms. Participants stop their current antipsychotic and take the study drug to see if it can help control symptoms.
Culver City, CaliforniaAges 18–65 - NCT07010614Recruiting
Brain stimulation for memory in schizophrenia
This trial uses brain stimulation to target memory areas in people with schizophrenia or related conditions. It aims to see if this can help improve symptoms.
Stanford, CaliforniaAges 18–65 - NCT06963034RecruitingPhase 3
Study of a new medicine for adults with schizophrenia
This trial tests an investigational medicine called NBI-1117568 in adults with schizophrenia who are currently having a relapse or worsening of symptoms and need to stay in the hospital. The goal is to see if the medicine is safe and effective.
Anaheim, CaliforniaAges 18–65 - NCT06961968RecruitingPhase 3
Schizophrenia medication withdrawal study
This study tests whether patients with schizophrenia can safely stop or reduce their current medication without worsening symptoms. It is designed for people who need ongoing psychiatric care.
Costa Mesa, CaliforniaAges 18–65 - NCT04807530Recruiting
MRI brain study for people with schizophrenia symptoms
This study uses brain scans to look at how a specific brain area works in schizophrenia. If you qualify, it may help researchers better understand the brain changes linked to symptoms.
San Francisco, CaliforniaAges 18–64 - NCT06502964RecruitingPhase 2
ALTO-101 study for schizophrenia cognitive symptoms
This study tests an experimental medication called ALTO-101 for people with schizophrenia who also have cognitive impairment (memory or thinking problems). It aims to see if the drug can improve these symptoms while you continue your current antipsychotic treatment.
Garden Grove, CaliforniaAges 21–55
Schizophrenia trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting schizophrenia studies listed above.
- Neurocrine Clinical Site · 4 studies
- ProScience Research Group · 3 studies
- Collaborative Neuroscience Research, LLC · 2 studies
- Advanced Research Center (ARC)
- California Clinical Trials Medical Group - Parexel /ID# 275751
- Catalina Research Institute
- CenExel
- CenExel CIT (Clinical Innovations, Inc.)
What taking part in a schizophrenia study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Schizophrenia trials in other states
Common questions
- Are there schizophrenia clinical trials in California?
- Yes. We're currently tracking 50 recruiting schizophrenia studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a schizophrenia study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a schizophrenia trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New schizophrenia studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.