Clinical trials
Somatic Mutation clinical trials
Below are recruiting somatic mutation clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06585800Enrolling by invitation
Studying gene changes in tissues
This study looks at genetic changes that occur naturally in human tissues. If you are already scheduled for surgery or a procedure like a biopsy or endoscopy, researchers may ask for a small tissue sample to study how our cells can change over time.
CambridgeAges 18 years+ - NCT06851052Enrolling by invitation
How do DNA changes happen in health and disease?
This study is looking at DNA changes (mutations) in healthy people and in people who may have DNA damage from things like the sun, smoking, past diseases, or treatments like radiation. The goal is to better understand how these changes happen and what they mean.
CambridgeAges 18 years+ - NCT01994057Recruiting
Looking back at EGFR-targeted pills for lung cancer
This study looks back at how people with non-small cell lung cancer (NSCLC) were treated with EGFR-targeted medicines (gefitinib, erlotinib, and osimertinib). It may help doctors understand which patients benefit most and what side effects to expect.
Guangzhou, GuangdongAges 18–85 - NCT06832150Enrolling by invitation
How cancer treatment affects normal cells
This study looks at how cancer therapies may change healthy cells in your body over time. By collecting samples before and during treatment, researchers hope to understand long-term effects of therapy on normal tissues.
CambridgeAges 18–99 - NCT06357845Recruiting
East Palestine chemical exposure and genetic change study
This study looks at whether the chemical spill in East Palestine in 2023 caused changes in people's genes. It involves giving a blood or saliva sample to measure any tiny genetic changes linked to the exposure. It helps researchers understand long-term health risks.
Cleveland, OhioAges 18 years+ - NCT06656767Enrolling by invitation
Studying liver cell changes in chronic liver disease
This trial uses already collected liver tissue samples from adults to study how cells change over time in chronic liver disease. It could help researchers understand the disease better and find new ways to treat it.
CambridgeAges 18 years+ - NCT05735717RecruitingPhase 2
T-cell transplant using depleted receptors for blood cancers
This Phase 2 study tests a specialized stem cell transplant that removes certain immune “T-cell” receptors to help treat blood cancers like acute leukemia. It may help your body rebuild a healthier immune system after high-dose treatment.
Minneapolis, MinnesotaAges Up to 60 years - NCT06917794Enrolling by invitation
Genetic risk study for colon cancer patients
This study looks at how your genetic background and ancestry affect your risk for colon cancer. If you have been diagnosed with colon cancer and have a tumor sample available, you may be able to help researchers develop better risk scores.
Fortaleza, CearáAges 18 years+ - NCT06054295Recruiting
Twin study of childhood brain tumors
This study looks at genetic differences between identical twins where only one twin has a childhood brain or spinal cord tumor. It helps researchers understand why some children get cancer and others don't.
Minneapolis, MinnesotaAges Up to 18 years - NCT05014165Recruiting
Cord blood study for leukemia with stored birth samples
This study looks at leukemia “genetic clues” using special stored samples, including cord blood saved at birth. It may help researchers better understand leukemia biology and how common mutations may show up early.
Minneapolis, MinnesotaAges Up to 25 years - NCT05364294Recruiting
Molecular testing for rare inflammatory (autoinflammatory) diseases
This study uses lab testing to better identify the cause of certain rare inflammatory conditions that happen without infection. Finding the cause may help doctors choose more targeted care for you or your child.
ParisAges 1 week–120 years - NCT06194669Recruiting
VHL disease and kidney tumor risk study
This study looks at how early changes in kidney cells can lead to tumors in people with VHL disease. It may help understand why some people develop kidney cancer and how to prevent it.
MilanAges 18 years+ - NCT06494358Recruiting
Blood tests to find genetic changes in brain AVM
This trial uses a blood test to look for genetic mutations in brain arteriovenous malformations (bAVMs). It may help doctors understand these lesions better and guide treatment.
ParisAges 18 years+ - NCT03901521Enrolling by invitation
Biobank for people with autosomal dominant polycystic kidney disease
This study collects samples and health information from adults with autosomal dominant polycystic kidney disease (ADPKD) who are having their own kidney removed. It helps researchers learn more about ADPKD and its genetic changes to support future treatments.
New York, New YorkAges 18–100
Hear when a new Somatic Mutation trial opens
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Common questions
- Are there clinical trials for somatic mutation?
- Yes. Clin2 currently lists 14 recruiting somatic mutation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a somatic mutation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a somatic mutation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.