Clinical trials
Toothbrushing clinical trials
Below are recruiting toothbrushing clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07030088Recruiting
Testing a new two-sided toothbrush for healthier gums
This trial tests a special toothbrush that cleans both sides of your teeth at once. It compares this new brush to a regular one to see if it improves gum health in dentists.
RiyadhAges 25–40 - NCT06122805Recruiting
Electric vs. Manual Toothbrush for Kids with Cleft Lip/Palate
This study compares a special dual-light electric toothbrush to a regular manual toothbrush for kids and teens with cleft lip or palate who wear braces. The goal is to see which brush keeps teeth cleaner and gums healthier during orthodontic treatment and after oral surgery.
Los Angeles, CaliforniaAges 6–20 - NCT07306026Recruiting
Testing a toothbrush's bristles on plaque and gums
This trial compares how well different toothbrush bristles remove plaque and affect gum health. It may help find the best toothbrush design for everyday oral care.
Buffalo, New YorkAges 18–70 - NCT07155798Recruiting
Bamboo vs. plastic toothbrush for plaque removal in teens
This trial compares a bamboo toothbrush to a regular plastic toothbrush to see which one does a better job removing plaque. If you are a teenager in good health, you can help find out which brush is better for your teeth and the planet.
CairoAges 12–18 - NCT07779564Recruiting
Electric flosser study for plaque and gum health
This study tests whether an electric flosser is better than a manual toothbrush for reducing plaque and gum inflammation. Participants will use the electric flosser for 30 days while having regular checkups. This could help you learn a new way to improve your oral health.
Fort Wayne, IndianaAges 18–70 - NCT07200297Recruiting
Comparing three mouth care methods for ICU patients on non-invasive ventilation
This study compares three different mouth care methods for patients in the intensive care unit who are using a non-invasive ventilator (a mask or mouthpiece). The goal is to find the best way to keep the mouth clean and comortable during their stay.
Erzurum, MerkezAges 18 years+ - NCT06208722Recruiting
Testing a toothbrushing app for teens with autism
This study tests a mobile app designed to help teens with autism improve their toothbrushing skills and build a daily habit. Your family will use the app at home, and researchers will see if it makes brushing easier and more consistent.
Seattle, WashingtonAges 10–17 - NCT07619014Recruiting
Miswak vs. toothbrush for cleaning teeth with braces
This study compares how well a miswak (a natural chewing stick) and a regular toothbrush remove plaque buildup around orthodontic braces. If you wear braces, this trial tests whether miswak might be an equally effective cleaning option.
HomsAges 18–30 - NCT05945225Enrolling by invitation
Oral care during pregnancy to reduce gum inflammation
This study looks at how a specific oral care approach during pregnancy may lower gum inflammation. It mainly enrolls pregnant people in mid-pregnancy and checks gum health over time.
NancyAges 18–40 - NCT05851963Recruiting
Toothbrushing help for teens with fixed braces
This study looks at whether using specific toothbrushes in daily life can improve dental gum and tooth health for teens with fixed braces. It may help by testing simple at-home brushing routines that could reduce gum problems during orthodontic treatment.
NancyAges 11–15 - NCT06352645Recruiting
Testing a compact water flosser for gum health
This trial tests a new water flosser (Bixdo Ultra Compact) to see if it safely improves gum health in people with moderate to severe gum disease. You would use the flosser at home and attend check-ups for about 4 weeks.
Boston, MassachusettsAges 18–70 - NCT07441148Recruiting
Digital vs. parent-led toothbrushing for kids
This study compares two ways of teaching children how to brush: with a digital tool or by having a parent show them. It looks at how well they brush and how their teeth look after brushing.
Los Angeles, CaliforniaAges 3–6 - NCT05965076Recruiting
Test glycine powder and a special brush for oral care
This trial studies whether using glycine powder and an angled implant brush helps keep dental implants healthy in people following the Columbus Bridge ProtocolTM. It may help by improving daily oral hygiene around implants and reducing implant problems.
TorinoAges Any age - NCT06671106Recruiting
Mouthrinse for Teens with Early Gum Disease
This trial tests a special mouthrinse containing amine and zinc lactate to treat plaque-induced gingivitis (gum inflammation caused by plaque) in teenagers. If you or your teen have early gum disease and are eligible for free dental care through the Regional Health Service, this study may offer a home-based treatment option.
FerraraAges 12–14 - NCT07549347Recruiting
Smart Toothbrush vs. Professional Cleaning for Gum Disease
This study tests whether using an intelligent (electric) toothbrush with a smartphone app can manage early gum inflammation as effectively as professional dental cleaning. If you have mild gum disease, this trial may help you avoid or delay professional treatments.
Shanghai, Shanghai MunicipalityAges 18–64 - NCT07611942Recruiting
Plaque Removal in Children With Learning Disabilities
This study compares how well children with learning disabilities can remove plaque from their teeth compared to children without learning disabilities. It aims to understand if dental plaque removal is harder for children with specific learning challenges.
Alanya, AntalyaAges 7–12 - NCT07446413Enrolling by invitation
App to improve toothbrushing in kids with autism
This study tests a mobile app designed to help children and teens with autism improve their toothbrushing habits. Your child will use the app at home, and the study looks at whether it makes brushing easier and more fun.
Seattle, WashingtonAges 8–17 - NCT06980714Enrolling by invitation
Electric vs. manual toothbrush for advanced gum disease
This study compares electric and manual toothbrushes to see which one works better for people with advanced gum disease (stage 3 or 4 periodontitis). It might help you find a more effective way to care for your teeth and gums at home.
L’AquilaAges 18 years+
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Common questions
- Are there clinical trials for toothbrushing?
- Yes. Clin2 currently lists 18 recruiting toothbrushing studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a toothbrushing trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a toothbrushing trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.