Treatment
Methadone clinical trials
We’re tracking 41 recruiting studies that include Methadone, each written for real people, not researchers, below.
Recruiting studies
- NCT07226076RecruitingPhase 3
Methadone for knee replacement pain and less opioids
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Charleston, South CarolinaAges 18–75 - NCT07227064RecruitingPhase 3
Methadone for pain relief after hip replacement surgery
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Charleston, South CarolinaAges 18–75 - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75 - NCT06835582Enrolling by invitation
Checking Methadone and Its Breakdown Levels
This study is checking the levels of methadone and its breakdown products in your blood. It helps make sure the medication is working safely for conditions like opioid use disorder or chronic pain.
Lemon Grove, CaliforniaAges 18–70 - NCT05675735Recruiting
Methadone take-home program to help people stay in treatment
This trial studies whether changing how methadone is allowed to be taken home can improve how long people stay in opioid use disorder treatment. It focuses on clinics and on adults who have already been receiving take-home methadone.
Storrs, ConnecticutAges 18 years+ - NCT05490732Recruiting
Methadone dose blood-level study and monitoring
This study measures how methadone moves through your body by using planned blood samples and computer modeling. It may help doctors better predict methadone levels to support safer dosing for people already taking methadone.
MontpellierAges 18–99 - NCT06556602Recruiting
Study to improve access to methadone treatment
This trial tests a new way to help people get methadone treatment by working with staff at opioid treatment programs. It might lead to better access for patients.
Tucson, ArizonaAges 18 years+ - NCT05942313Recruiting
Predicting and preventing problems from opioid use during pregnancy
This study looks at ways to predict and reduce harmful outcomes for pregnant people with opioid use disorder (OUD) and their babies. It focuses on people who are already receiving ongoing medication treatment during pregnancy and will follow them around delivery at a specific hospital.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT06032559RecruitingPhase 3
Mindfulness and methadone for chronic pain
This study tests if adding a mindfulness program (MORE) to regular methadone treatment helps people with long-term pain. It may improve pain and support recovery.
New Brunswick, New JerseyAges 18 years+ - NCT06338280RecruitingPhase 2
Observing methadone treatment remotely
This study tests if using a smartphone app to watch you take your methadone works as well as going to a clinic every day. It might make treatment easier for you.
Chicago, IllinoisAges 18–64 - NCT06527820Recruiting
Talking about buprenorphine and methadone for opioid use
This trial is testing a conversation approach to help people start medication for opioid use disorder (like buprenorphine or methadone). It may be a good fit if you've had an overdose, opioid withdrawal, or other serious problem from opioid use and are not already on these medications.
Springfield, MassachusettsAges 18 years+ - NCT06576830RecruitingPhase 4
Pain relief study for kids having tonsil surgery
This study tests different ways to manage pain after tonsillectomy in children. The goal is to find better pain relief options.
Durham, North CarolinaAges 3–17 - NCT06877858RecruitingPhase 1
MethaLoad dose-finding study for opioid use disorder
This study tests a new way to start methadone treatment (called 'MethaLoad') for people with opioid use disorder who have used fentanyl. If you qualify, you will receive methadone to help manage withdrawal and reduce cravings, and the doctors will closely monitor your safety and response.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT07085377Recruiting
Nurse-led methadone program for opioid use disorder
This trial tests a system where nurses can adjust your methadone dose without a doctor's order. It's for people starting methadone treatment for opioid use disorder and willing to be followed at a CSAPA center for 3 months.
BayonneAges 18 years+ - NCT07251283Recruiting
Food insecurity and eating in opioid treatment
This study looks at how food insecurity (not having enough to eat) affects eating habits in people taking methadone or buprenorphine for opioid use disorder. The goal is to learn more about food access and help improve support for people in treatment for opioid addiction.
Burlington, VermontAges 18 years+
Common questions
- Are there clinical trials studying Methadone?
- Yes. Clin2 currently lists 41 recruiting studies that include Methadone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Methadone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Methadone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Methadone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.