Treatment
Methadone clinical trials
We’re tracking 41 recruiting studies that include Methadone, each written for real people, not researchers, below.
Recruiting studies
- NCT05981573Recruiting
Measuring methadone doses for chronic pain
This trial is for people with chronic pain who take daily methadone. It aims to measure how much methadone is in your body to help doctors find the right dose.
Lemon Grove, CaliforniaAges 18–70 - NCT07221617RecruitingPhase 4
Methadone for pain after heart surgery
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
Rochester, MinnesotaAges 18 years+ - NCT05789173RecruitingEarly Phase 1
Testing how genetics affect drug levels with methadone
This early study tests how a person’s genetic makeup may change how fast certain medicines move through the body. It compares drug levels when combined with methadone and tizanidine, aiming to understand safer dosing and effects.
Indianapolis, IndianaAges 18–65 - NCT05459402RecruitingPhase 2/Phase 3
Methadone dose testing for opioid use disorder pain relief
This study compares taking methadone as one dose versus split into two doses to see which approach works better for people who have pain. It’s meant for adults already on a steady methadone program and who can follow study visits and procedures.
Baltimore, MarylandAges 18–100 - NCT06626035RecruitingPhase 3
Pain Medicine Study for Children Having Heart Surgery
This study tests a pain medicine for children having heart surgery. It aims to see if the medicine works well and is safe for managing pain after the operation.
Oakland, CaliforniaAges 3–18 - NCT03168958RecruitingPhase 4
Methadone to improve recovery after planned heart surgery
This trial looks at whether giving methadone during planned heart surgery can improve how patients feel and recover afterward. It will mainly compare recovery quality using a patient questionnaire.
Evanston, IllinoisAges 18–90 - NCT06626503RecruitingPhase 3
Pain medicine study for children having spine surgery
This study tests a pain medicine (methadone) for children and teens having spine fusion surgery for scoliosis. It aims to see if it helps control pain safely.
Cincinnati, OhioAges 10–18 - NCT06525740RecruitingPhase 4
Comparing two pain medicines for gynecologic cancer surgery
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Rochester, MinnesotaAges Any age - NCT05831345RecruitingPhase 3
Methadone during surgery to prevent post-surgery pain
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
BrusselsAges 18–80 - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT07365800Enrolling by invitationPhase 4
Combination pain control after complex spine surgery
This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.
Columbia, MissouriAges 18–79 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT03893734RecruitingPhase 4
Methadone vs hydromorphone to check heart rhythm after surgery
This trial tests whether the pain medicines methadone and hydromorphone affect the heart’s electrical timing after general anesthesia and surgery. It may help doctors choose the safer option for patients who need strong pain control after an operation.
Evanston, IllinoisAges 18–80 - NCT06784999RecruitingPhase 4
Pain relief after head and neck reconstructive surgery
This study compares two medicines, sufentanil and methadone, for pain control after head and neck surgery that uses a flap to rebuild tissue. The goal is to find which option works better and has fewer side effects.
Indianapolis, IndianaAges 18–80 - NCT07517679RecruitingPhase 4
Methadone for Pain After Spine Surgery
This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.
Lexington, KentuckyAges 18–120 - NCT07314346RecruitingPhase 1
Study of a new hepatitis C drug with addiction medications
This study checks how a new hepatitis C medicine (bemnifosbuvir/ruzasvir) interacts with medications used for opioid addiction, such as buprenorphine/naloxone or methadone. It helps doctors understand if the new medicine is safe and effective for people taking these addiction treatments.
Hollywood, FloridaAges 18–65 - NCT06415994Enrolling by invitation
Placental imaging and outcomes in opioid use disorder in pregnancy
This study looks at how the placenta and baby's development may be affected when a mother takes buprenorphine or methadone for opioid use disorder during pregnancy. It aims to find better ways to monitor health and improve outcomes for both mothers and babies.
Indianapolis, IndianaAges 18–100 - NCT06323824RecruitingPhase 4
Methadone vs. buprenorphine for opioid use disorder treatment
This study compares two medications, methadone and buprenorphine, to see which helps people stay in treatment for opioid use disorder. You may be eligible if you are starting a new treatment episode.
Oakland, CaliforniaAges 18–99 - NCT06387303RecruitingEarly Phase 1
Comparing IV Methadone vs Spinal Morphine for Pain After Abdominal Surgery
This study compares two strong painkillers—methadone given through an IV versus morphine injected into the spine—to see which provides better pain relief and recovery after major abdominal surgery. It may help you if you're having open surgery and want less pain afterward.
Charlottesville, VirginiaAges 18–75 - NCT06536517RecruitingPhase 2
Methadone during hysterectomy to reduce pain pills
This study tests whether a single dose of methadone given during minimally invasive hysterectomy (for non-cancer reasons) can reduce the need for opioid pain pills after surgery. It aims to see if this approach helps with pain control and lessens opioid use.
Baltimore, MarylandAges 18 years+ - NCT06593665RecruitingPhase 3
Morphine in spine vs. IV methadone for testicular cancer surgery pain
This trial compares two ways to manage pain after surgery for testicular cancer: a single injection of morphine into the spine (intrathecal morphine) vs. methadone given through an IV during surgery. The goal is to see which provides better pain relief and fewer side effects.
Indianapolis, IndianaAges 18–80 - NCT06728371RecruitingPhase 3
IV methadone for pain after heart surgery
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
Hong KongAges 18 years+ - NCT06810336RecruitingEarly Phase 1
Pain control after brain surgery: methadone vs remifentanil
This trial compares two medicines, methadone and remifentanil, to see which one works better for pain after brain surgery. It may help improve your recovery and comfort.
Charlottesville, VirginiaAges 18–65 - NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72
What Methadone is being studied for
Conditions with recruiting Methadone studies.
Common questions
- Are there clinical trials studying Methadone?
- Yes. Clin2 currently lists 41 recruiting studies that include Methadone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Methadone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Methadone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Methadone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.