Understanding and Diagnosing Pheochromocytoma and Paraganglioma
Treatments studied
Part of Cancer, Hormones & metabolism clinical trials.
This study helps doctors better understand and diagnose pheochromocytoma and paraganglioma—rare tumors that release stress hormones and cause high blood pressure and other symptoms. Researchers will study your medical history, blood and urine tests, imaging scans, and genetic information to improve how these conditions are found and understood.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 3 years old with suspected or confirmed pheochromocytoma/paraganglioma (a rare hormone-releasing tumor)
- You have high levels of stress hormones in blood or urine, imaging findings suggestive of the tumor, or a personal or family history of this condition
- You have a regular doctor or endocrinologist (hormone specialist) who can help manage your care
- If you are a woman who could become pregnant, you cannot be pregnant or breastfeeding during the study
- You do not have severe heart problems or require kidney dialysis
- For imaging scans, you must be able to lie still and be willing to return to NIH for follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early study uses a special PET/CT scan to see how much a specific cancer-related protein (PARP-1) is present in pheochromocytoma and paraganglioma. It may help doctors understand the biology of these tumors and how useful this scan could be in the future.
This trial studies Lu-177 DOTATATE (Lutathera), a targeted radiation medicine, for tumors that cannot be safely removed with surgery. It aims to shrink or control pheochromocytoma/paraganglioma that is showing recent growth and has a specific target signal on a special PET scan.
This study looks at people who have been newly diagnosed with pheochromocytoma/paraganglioma (PPGL), those with a past history of PPGL, or those with genetic risk for it. It may help doctors better evaluate and understand PPGL using specific tests.
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This study looks at genetic (DNA) changes in people with pheochromocytoma or paraganglioma and related conditions. It may help clarify why these conditions happen and how they run in families.
This study uses a special PET scan (called 18F-mFBG) to get clearer pictures of pheochromocytoma, a rare adrenal tumor. It may help doctors better understand your tumor and guide treatment.
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