Brain-gut sensitivity study in IBS and inflammatory bowel disease
Part of Digestive system clinical trials.
This study checks how sensitive your gut is to normal stimuli in people with IBS, ulcerative colitis, Crohn’s disease, and in healthy volunteers. Results may help researchers understand why some people feel more abdominal discomfort and how that connects to inflammatory bowel conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have one of these: IBS; active or remission ulcerative colitis; active or remission Crohn’s disease; or no abdominal pain (healthy control).
- If you have ulcerative colitis or Crohn’s disease: you must have had it confirmed by at least one sigmoidoscopy.
- If you are in the “in remission” groups: your remission must be confirmed by at least one sigmoidoscopy (and for the IBS-symptom remission group, you meet IBS symptom criteria).
- If you take medicines that affect gut movement or gut feeling: you must stop them at least 24 hours before the study (your study team will guide which ones).
- You should not have severe kidney or liver disease, serious thyroid problems, or clotting problems.
- You should not have had abdominal surgery recently/at all, except for a simple appendectomy. (A history of other abdominal surgery may exclude you).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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