HIPEC during interval surgery for advanced ovarian cancer
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial looks at whether a heated chemotherapy treatment given in the abdomen during a planned second surgery (HIPEC) can improve outcomes for certain advanced ovarian cancers. It is for people who have already had initial chemotherapy and partially responded, with enough health to safely undergo surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are under 70 years old.
- Your cancer diagnosis is high-grade serous ovarian cancer and low-grade endometrioid cancer confirmed by biopsy (histology).
- Your cancer is stage IIIC or IV, and you have received 3–4 cycles of carboplatin and paclitaxel chemo.
- After this first chemotherapy, scans and blood tests show a partial response: at least a 50% drop in CA-125 and meeting scan response rules.
- You can have surgery safely: good heart function (ejection fraction >55%), good kidney/liver/blood counts, and enough lung function; ECOG performance status is 0–1.
- During interval surgery you must be left with very small remaining tumor (less than 2.5 mm).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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