Clin2
NCT03366051Possibly a fitRecruiting

Check mapping of the first lymph node in high-risk uterine cancer

Endometrial CancerLymph Node Metastases

Part of Cancer, Women’s health & pregnancy clinical trials.

This trial studies how to find the “sentinel” (first) lymph node during surgery for high-risk endometrial (uterine) cancer. It may help surgeons better tell whether cancer has spread to nearby lymph nodes and guide the extent of lymph node removal.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
178 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You have high-risk endometrial cancer based on the tumor type and grade (for example grade 3 endometrioid, serous, clear cell, or carcinosarcoma).
  • Or you have lower-grade cancer (endometrioid grade 1–2) with deep spread into the uterus muscle (myometrial invasion of 50% or more).
  • Or you have endometrioid grade 1–2 cancer that has spread into the cervix (the lower part of the uterus).
  • Your treatment plan includes a planned full lymph node removal surgery (systematic lymphadenectomy).
  • You can give informed consent for the study.
  • If you’ve already had pelvic lymph node surgery, or your hysterectomy was done elsewhere, you likely can’t join.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04845828Recruiting
Sentinel node biopsy versus full node removal in early uterine cancer

This study compares two ways to check lymph nodes during surgery for early-stage endometrial (uterine) cancer: sentinel node biopsy versus removing more lymph nodes. It may help find whether the less extensive approach can stage the cancer accurately with fewer side effects.

Seoul
NCT06900582Not yet recruiting
Comparing two lymph node surgeries for certain endometrial cancers

This trial tests whether removing only the first lymph node to detect cancer spread (sentinel node mapping) is as effective as removing all lymph nodes in the pelvic area (comprehensive lymphadenectomy) for a specific type of endometrial cancer with a p53 mutation, stages I–II. The goal is to see if the less extensive surgery can result in similar outcomes while possibly reducing side effects.

NCT05793333Recruiting
Study looks at what predicts lymph node spread in uterine cancer

This study uses tumor tissue and genetic test results to understand which features predict whether lymph nodes (sentinel nodes) are cancer-positive in endometrial (uterine) cancer. It mainly helps doctors improve how they predict spread and tailor care.

Milan, Lombardy
NCT04403867Recruiting
Study of tiny cancer spread found in sentinel lymph nodes

This trial studies whether very small deposits of cancer (called micrometastasis or isolated tumor cells) are found in sentinel lymph nodes in early endometrial or cervical cancer. The goal is to better understand what these findings may mean for cancer spread and treatment planning.

Milan
NCT07702721Not yet recruiting
Looking at lymph nodes during gynecologic cancer surgery

This trial tests a new way to look at lymph nodes during surgery for gynecologic cancers. It may help doctors decide immediately if cancer has spread to the lymph nodes, which could guide treatment decisions during the same operation.

NCT06677112Recruiting
Comparing lymph node removal methods for endometrial cancer

This trial compares two ways to remove lymph nodes during hysterectomy for endometrial cancer that hasn't spread. The goal is to find which method works better with similar or fewer side effects.

Lexington, Kentucky

Hear when a new Endometrial Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.