Ivacaftor for sinus problems linked to faulty CFTR
Part of Ear, nose & throat clinical trials.
This early-phase study tests whether ivacaftor can improve chronic sinus disease caused by problems with a specific body channel called CFTR. It may help some people whose sinus imaging, cultures, and prior sinus surgery match the study’s criteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and can give consent
- Your chronic sinus disease (CRS) was diagnosed by the study team
- You had a recent CT scan (within 30 days) showing specific sinus changes and you had prior sinus surgery with exposed maxillary and ethmoid sinuses
- Within 30 days, you had a positive sinus culture for a gram-negative bacteria (such as Pseudomonas or E. coli)
- You can do the study’s special nasal/sinus test (EDSPD) using enough space for a catheter
- If you can get pregnant, you must have a negative pregnancy test within 72 hours before starting treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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