Rethinking early airway clearance in cystic fibrosis
Part of Digestive system, Genetic & congenital, Lungs & breathing clinical trials.
This study looks at whether starting airway clearance techniques (like exercises or devices to clear mucus from the lungs) earlier in the day works better for children with cystic fibrosis who are already taking a CFTR modulator medication. It aims to find a simple, effective routine to help keep lungs healthy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 3 and 16 years old.
- You must have a confirmed diagnosis of cystic fibrosis.
- You must be taking either Trikafta (elexacaftor/tezacaftor/ivacaftor) or a similar medication (vanzacaftor/tezacaftor/deutivacaftor) for at least 90 days and plan to keep taking it.
- You must be feeling well — no major health changes or new antibiotics in the last 28 days.
- If you can do a lung function test, your FEV1 score needs to be 70% or more of what's expected for your age and height.
- You must be able to complete a special breathing test called a 'multiple breath washout' (MBW) at the screening visit.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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