Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,266 recruiting studies in this area right now.
By phase
- Not applicable888
- Phase 2153
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- Cairo University13
- NYU Langone Health13
- National Cancer Institute (NCI)13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland37
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,266 total
- NCT07667400RecruitingPhase 1/Phase 2
Docetaxel plus SX-682 for advanced head and neck or prostate cancer
This trial studies a combination of the chemotherapy drug docetaxel and an investigational drug called SX-682 for people with certain advanced head and neck cancers or prostate cancer. The goal is to see if the combination is safe and effective.
Bethesda, MarylandAges 18–120 - NCT07027826Recruiting
String test for eosinophilic esophagitis in African patients
This study tests a new, less invasive way (the Esophageal String Test) to look for signs of eosinophilic esophagitis—an allergic condition that can make swallowing painful or difficult. It is for people of African descent who have trouble swallowing and are already having an endoscopy.
Bethesda, MarylandAges 18–65 - NCT07796789RecruitingPhase 3
Preventing appetite loss during cancer treatment for nasopharyngeal carcinoma
This trial tests whether a medicine called nanocrystalline megestrol acetate can help prevent loss of appetite caused by chemotherapy and radiation therapy in people with nasopharyngeal carcinoma. If you are receiving chemoradiotherapy for this type of cancer, you may be able to participate.
Guangzhou, GuangdongAges 18–70 - NCT03625011RecruitingPhase 4
Gabapentin before tonsil surgery to reduce pain
This trial tests whether giving gabapentin before pediatric tonsil (and possibly adenoid) removal can reduce postoperative pain. It may help children feel more comfortable after surgery while still being safe to use in the right patients.
Atlanta, GeorgiaAges 3–18 - NCT04136886RecruitingPhase 3
Chemo trial for return of advanced nasopharyngeal cancer
This Phase 3 study tests a chemotherapy plan for people whose nasopharyngeal cancer has come back locally (T3/T4). It aims to see if treatment given after return of cancer can help control the disease without spreading to distant organs.
Guangzhou, GuangdongAges 18–70 - NCT04192656RecruitingPhase 4
PAP treatment for sudden hearing loss with sleep apnea
This trial tests whether using PAP (a breathing device for sleep apnea) can improve sudden hearing loss that happens alongside obstructive sleep apnea. It may help by reducing stress on the body during sleep and supporting hearing recovery.
Beijing, Beijing MunicipalityAges 18–70 - NCT04453826RecruitingPhase 3
Test PD-1 plus chemo-radiation for high-risk nasopharyngeal cancer
This Phase 3 trial tests whether adding a PD-1 immunotherapy (given with chemotherapy and radiation, and also after) can improve outcomes for people with high-risk nasopharyngeal cancer. It may help by strengthening the immune system’s attack on the cancer alongside standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT04453813RecruitingPhase 3
Immunotherapy with chemoradiation for recurring nasopharyngeal cancer
This phase 3 trial tests whether adding toripalimab (an immunotherapy medicine) to standard chemo-radiation works better for treating nasopharyngeal cancer that has come back and cannot be removed by surgery. It aims to improve control of the cancer after it returns.
Guangzhou, GuangdongAges 18–70 - NCT04448522RecruitingPhase 3
Lower-dose radiotherapy for EBV-responsive nasopharyngeal cancer
This Phase 3 study tests whether giving a reduced amount of radiotherapy can work as well as the standard dose for certain people with stage II–III nasopharyngeal cancer who respond well after initial chemotherapy. It’s designed for patients whose cancer markers improve after 3 chemotherapy cycles, to potentially reduce treatment side effects while keeping cancer control.
Guangzhou, GuangdongAges 18–70 - NCT04665726Recruiting
Natural history study of Usher syndrome hearing and vision changes
This study follows people with Usher syndrome over time to better understand how hearing and vision symptoms change. It may help researchers measure disease progression and support future treatments.
ParisAges Any age - NCT04778956RecruitingPhase 3
Toripalimab plus surgery vs surgery alone for recurring throat cancer
This trial tests whether adding toripalimab (an immune therapy) to surgery helps people with recurrent nasopharyngeal cancer live longer or control the cancer better than surgery alone. You may qualify if your recurrence can be fully removed by surgery and it came back after a certain amount of time.
Guangzhou, GuangdongAges 18–70 - NCT03353467Recruiting
Surgery through the nose for early nasopharyngeal cancer
This trial tests whether a minimally invasive surgery done through the nose can help people newly diagnosed with early-stage nasopharyngeal cancer. It looks for patients who have not had prior cancer treatment and who are healthy enough for the procedure and follow-up.
Guangzhou, GuangdongAges 18–70 - NCT04376866RecruitingPhase 3
Immunotherapy for repeat nasopharyngeal cancer after it returns
This trial studies toripalimab (an immunotherapy that helps your immune system attack cancer) for nasopharyngeal cancer that has come back locally. It may help shrink or control the returning tumor and improve outcomes for people who meet the safety and lab requirements.
Nanning, GuangxiAges 18–65 - NCT04070937Recruiting
Imaging findings and balance function in bilateral vestibulopathy
This study compares CT/MRI imaging results (radiological lesions) with balance system function tests in people with bilateral vestibulopathy. The goal is to see whether changes seen on scans match how well your inner-ear/balance nerves are working, which could improve understanding and future treatment decisions.
Hasselt, LimburgAges 18–90 - NCT05062005RecruitingPhase 3
Tests two ways of treating locally advanced nasopharyngeal cancer
This phase 3 trial compares a standard treatment plan (CRT) versus a new approach (ICCRT) for people with locally advanced nasopharyngeal cancer, without spread to distant organs. It aims to see which plan works better and is safe for tumors in the head and neck area.
Guangzhou, GuangdongAges 18–65 - NCT03716908Recruiting
Study of hearing gene changes in DFNA9 family members
This study looks at how a specific inherited gene change (the P51S COCH mutation) connects to hearing and balance symptoms over time. It may help researchers better predict who will develop symptoms and how they may progress.
AntwerpAges 18 years+ - NCT05126160Recruiting
MRI-based imaging to guide treatment in nasopharyngeal cancer
This study uses special MRI images (and computer “radiomics” scores) to better understand nasopharyngeal cancer. The goal is to help doctors choose the most appropriate treatment for people with newly diagnosed cancer.
Wuhan, HubeiAges 18–70 - NCT04917367Recruiting
Treats confirmed foreign bodies outside the throat and esophagus
This trial focuses on people whose foreign body is found during surgery in an area outside the throat (pharynx) and esophagus. It tests how to diagnose and treat these situations after surgery confirms what was present.
Hangzhou, ZhejiangAges 18–70 - NCT05315791Recruiting
Bone-window dental procedure for missing back upper tooth
This study looks at how to place bone support for an upper back tooth replacement when part of the upper jaw bone is limited. If you’re missing one upper back tooth for at least 3 months, they may use a specific “bone window” approach guided by a 3D scan.
Hangzhou, ZhejiangAges 18–80 - NCT05342792RecruitingPhase 3
Chemo tablets with or without an immune therapy after cancer treatment
This trial tests whether taking the chemo tablet capecitabine after standard chemoradiation can help prevent cancer from coming back, and whether adding an immune therapy (a PD-1 antibody) improves results. It is for people with high-risk nasopharyngeal (throat) cancer whose main treatment has already finished.
Guangzhou, GuangdongAges 18–65 - NCT05348148Recruiting
Compare treatments for moderate to severe rhinitis symptoms
This trial compares different ways to reduce rhinitis symptoms in people with moderate to severe nasal irritation. It may help find which treatment works best for you, depending on what type of rhinitis you have and your recent health and medication history.
Luodong, YilanAges 6–65 - NCT04437329RecruitingPhase 3
Nedaplatin vs cisplatin for nasopharyngeal cancer
This trial compares two chemotherapy drugs—nedaplatin versus cisplatin—in people newly diagnosed with a specific type of nasopharyngeal cancer. The goal is to see which drug works better and/or has a safer side-effect profile when given as part of standard treatment.
Guangzhou, GuangdongAges 18–65 - NCT05350540RecruitingPhase 2
ICG dye to lower leakage after salvage laryngectomy surgery
This study tests whether using a special fluorescent dye (ICG) during salvage laryngectomy can reduce the chance of a surgical “leak” (a fistula) in the throat area. If you’re having salvage surgery after prior radiation, it may help surgeons better see where to place tissue coverage to prevent complications.
Toronto, OntarioAges 18 years+ - NCT05352321Recruiting
Surgery plus targeted chemoradiation versus standard chemoradiation
This trial compares two treatment plans for newly diagnosed, operable nasopharyngeal cancer: adding surgery plus targeted chemoradiation versus standard chemoradiation alone. It aims to see whether the surgery-based plan improves control of the cancer and related outcomes.
Guangzhou, GuangdongAges 18–70
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,266 recruiting otolaryngology studies from the U.S. registry right now, out of 2,063 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.