Injectable treatment before surgery for advanced melanoma
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether an injected medicine placed directly into melanoma tumors before surgery can improve outcomes for melanoma that has spread to nearby lymph nodes/skin but can still be fully removed. It aims to shrink the cancer and reduce the chance it comes back after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have melanoma confirmed by biopsy or cell test, in stage IIIB, IIIC, or IIID, and all visible tumor deposits can be fully removed by surgery.
- You have a measurable tumor lesion that a doctor can inject (skin, under the skin, or a lymph node), with enough size to measure (at least 10 mm total longest diameter).
- You are 18 years or older and can have the study visits and blood tests as planned.
- Your overall health is good enough for treatment: you have limited symptom impact (ECOG/WHO score 0–1) and enough blood counts (white cells, hemoglobin, and platelets).
- Your main organ tests are acceptable (liver, kidney, and LDH levels), and you have screened negative for HIV, hepatitis B, and hepatitis C (with specific extra rules for hepatitis B past exposure).
- You are not pregnant or breastfeeding, and you can use reliable birth control during the study and for a few months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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