Neoadjuvant, spare-adjuvant (NASA) in stage IIIB-IV (M1a) melanoma
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether giving immunotherapy before surgery and possibly skipping some after may help people with advanced but removable melanoma. It aims to see if this approach can reduce the chance of the cancer coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with melanoma (a type of skin cancer) that has spread to lymph nodes or nearby areas but can be completely removed with surgery.
- You have not had prior treatment with certain immunotherapies (PD-1 or CTLA-4 inhibitors).
- You do not have an active autoimmune disease that requires immunosuppressive treatment, though you may take up to 10 mg of prednisone daily.
- You are generally well enough to undergo treatment, with a performance status of 0-2 (able to care for yourself and perform daily activities).
- Your organ function (blood counts, kidney, liver, heart) is adequate as determined by tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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