Testing a new valve placed through a blood vessel
Part of Heart & circulation clinical trials.
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 70 years or older and can provide informed consent
- Your heart ultrasound tests show calcified aortic stenosis (severe narrowing) by set numbers
- You feel symptoms from this valve problem (NYHA class II or higher)
- A CT scan shows your valve opening size is between 21 and 23 mm
- You are considered high risk for surgery (based on risk scores or your heart team’s judgment)
- You can travel for and agree to follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new valve device placed through a small tube (catheter) to treat severe aortic stenosis, a condition where the aortic valve is narrowed and doesn't open fully. It's for patients who cannot have traditional open-heart surgery.
This study tests a new replacement valve for the aortic heart valve, delivered through a catheter (a thin tube) — a procedure called TAVR. It is for people who have severe aortic stenosis and are not good candidates for open-heart surgery.
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
This trial tests a new type of aortic valve replacement that can be inserted without open-heart surgery. It's designed for people with severe aortic stenosis who are not suitable for a standard operation.
This study looks at how safe and effective emergency aortic valve replacement is for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. It aims to help patients who are in critical condition, such as those in shock or with dangerous heart rhythms, by replacing the valve urgently.
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Hear when a new Severe Aortic Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.