Skip sentinel lymph node biopsy after breast cancer chemotherapy
Part of Cancer, Skin clinical trials.
This trial looks at whether some people with HER2-positive or HR-positive breast cancer can safely avoid a sentinel lymph node biopsy after chemotherapy. It tests a treatment approach based on how completely the breast tumor shrinks on MRI and whether lymph nodes look clear before treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult woman (18 or older)
- Have invasive breast cancer that is HER2-positive and/or hormone receptor positive
- Have a breast MRI done before starting chemotherapy and show a complete response after or during treatment
- Before chemotherapy, your lymph nodes must look clear on ultrasound and FDG-PET/CT (or any suspicious nodes test negative by biopsy)
- Have had at least 3 cycles of chemotherapy before the MRI result
- Have no breast tumor stage T4 and no breast cancer in the same breast before; also no other active cancers in both breasts or spread to distant organs (M1)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether patients with advanced breast cancer (with lymph node involvement) who shrink their cancer with chemotherapy before surgery can safely skip complete lymph node removal and just have a smaller sentinel node procedure instead. The goal is to reduce surgery-related side effects while maintaining good cancer outcomes.
This trial studies whether you can safely avoid a lymph node biopsy in the armpit for early breast cancer when scans and exams look negative. It may reduce surgery-related side effects while still keeping cancer care on track.
This trial studies whether taking a sample from the sentinel lymph node (a first lymph node that can be involved) improves care compared with observation, after a breast cancer PET scan of the armpit area. It may help people with certain early breast cancers avoid unnecessary procedures if the lymph nodes look negative on scans.
This trial checks if a breast biopsy can confirm that chemo has destroyed all cancer cells, so you might avoid surgery altogether. It's for people with aggressive breast cancer types who responded well to chemotherapy.
This study checks whether some people with breast cancer who have no remaining cancer after medicine (neoadjuvant systemic therapy) can safely receive less radiation. It may help reduce side effects while still keeping cancer controlled.
This study looks at a less invasive way to check and treat lymph nodes in the armpit after you receive chemotherapy (and sometimes immunotherapy) before breast surgery. It may help people with cancer that has already spread to armpit lymph nodes by improving how staging and treatment are done.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.