Surgery plus chemo versus chemo-radiation then surgery for recurrent rectal cancer
Part of Cancer, Digestive system clinical trials.
This study compares two treatment plans for locally recurrent rectal cancer: (1) surgery plus chemo, or (2) chemo plus radiation first, then surgery, followed by chemo. It aims to see which approach works better in controlling the cancer and helping patients recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your initial rectal cancer was an adenocarcinoma or adenosquamous cancer, confirmed by pathology (from surgery tissue or biopsy).
- Your cancer has come back after prior treatment, and the comeback is confirmed by pathology or scans (CT/MRI/PET) showing local recurrence or clear progression.
- Your recurrent tumor is located in the pelvis, and doctors think it can be surgically removed (not just endoscopically).
- No distant spread is present at the time of starting the study (cM0), and planned surgery is considered safe with good margins.
- You cannot have had prior surgery for the recurrent cancer or prior radiation to the pelvis.
- You must be 20–80 years old, well enough for treatment (ECOG 0–1), with blood counts and organ tests within limits, and able to sign consent.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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