Chemotherapy before surgery for rectal cancer vs chemo with radiation
Part of Cancer, Digestive system clinical trials.
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old
- You have been diagnosed with rectal adenocarcinoma (a type of rectal cancer)
- Your cancer has not spread to distant organs, and doctors think surgery can fully remove it
- Your rectal tumor is within 12 cm of the anus (checked by MRI)
- You have not had rectal surgery, chemotherapy, or radiation before (hormone therapy is an exception)
- You have enough blood, liver, and kidney function, and you feel fairly well (ECOG 0–1)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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