Diacerein to improve knee osteoarthritis symptoms
Part of Bones, joints & muscles clinical trials.
This Phase 3 study tests diacerein (Artrodar®) to see if it can improve symptoms in people with knee osteoarthritis, and it uses movement and scan-based assessments. It may help reduce walking pain and improve knee function for the right patient group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 40 to 65 with primary knee osteoarthritis (not a different type).
- Your knee X-ray severity is moderate (Grade II–III on the Kellgren-Lawrence scale).
- Your knee alignment is “bow-legged” (varus) no more than 15 degrees.
- Your BMI is 30 or less, and you have at least moderate pain when walking.
- You can provide pregnancy prevention methods if you could become pregnant.
- You’re able to attend regular study visits, including MRI scans if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how knee pain from osteoarthritis affects your daily life and health. You'll use a topical anti-inflammatory gel and answer questions by text or email for two months.
This trial tests whether a combination of platelet-rich plasma (a concentrate from your own blood) and hyaluronic acid (a joint lubricant) helps reduce pain and improve function in people with knee arthritis. You may be eligible if you have moderate knee pain but your other knee is relatively pain-free.
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
This trial studies whether different diet approaches can reduce knee pain in people with knee osteoarthritis who have certain eating patterns. It may help by changing diet-related factors that can affect inflammation and pain.
This study tests whether adding vitamin D to either omega-3 or metformin can help relieve pain and improve function in people with knee osteoarthritis. It may offer a new option for managing arthritis symptoms.
This study tests whether a new medicine (ALT001) can safely reduce knee pain from osteoarthritis. If you join, you would stop your current pain medicines and take the study drug or a placebo for a set time, while being closely monitored.
Hear when a new Knee Osteoarthritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.