Testing gentle stimulation of ovaries before fertility treatment
Part of Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial studies whether a “mechanical stimulation” procedure can help small egg-making structures in the ovary start to work again in people with primary ovarian insufficiency. If the procedure shows signs of response, you may then move on to further fertility treatment, including IVF.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 40 years old or younger and have primary ovarian insufficiency (ovaries stop working early).
- Your chromosome test (karyotype) must be normal, and it’s not due to a known genetic cause like Turner syndrome.
- Your BMI must be 35 or lower, and you’ve had little or no periods (oligo/amenorrhea) for at least 4 months.
- Blood tests should match the trial thresholds: FSH over 25 IU/mL and AMH 0.1 ng/mL or less.
- Ultrasound should show no follicles larger than 4 mm, and you must have two ovaries of about equal size.
- You must be willing to undergo surgery and possible IVF, and have a transvaginal ultrasound with Doppler (to check blood flow) before the procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether an injection of your own “platelet-rich” plasma into the ovaries can improve egg production in people who respond poorly to fertility treatment. It targets women with low egg reserve and tries to see if this approach helps them get better results from stimulation.
This trial studies whether an injection of your own PRP (platelet-rich plasma) can improve how your ovaries work in people with early ovarian failure. If it helps, it may lead to better hormone balance and return of more regular ovulation and periods.
This trial tests whether injecting your own platelet-rich plasma (PRP) into the ovaries can improve egg production in people who don’t respond well to fertility stimulation. It may help some “poor responders” get more usable eggs for IVF.
This trial tests whether injecting your own PRP (platelet-rich plasma) into the ovaries can improve ovarian function in some menopausal women. It may help those whose menopause seems less advanced, but not everyone will be eligible based on health and test results.
This trial tests a new way to stimulate ovaries after ovulation using a single injection of Elonva, compared to a standard method starting on day 2 of the menstrual cycle. It aims to see which approach leads to more mature eggs for IVF or ICSI.
This study tests whether a procedure that stimulates the outer layer of the ovary can help women with low egg reserves produce more eggs during fertility treatment. Women will undergo this procedure before starting IVF to see if it improves their chances of success.
Hear when a new Infertility, Female trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.