Stem cell transplant to protect salivary function after oral cancer
Part of Cancer clinical trials.
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have squamous cell carcinoma that started in the lining of the mouth/oral cavity.
- You had surgery to remove the tumor plus a neck dissection on the same side (at least neck levels Ib to III) that includes the submandibular gland.
- After surgery, you received radiation (or chemo-radiation) to the tumor area and the neck, including the opposite side neck levels Ib to IV.
- You do not have prior radiation to the head and neck (this study is not for “re-irradiation”).
- You do not have certain infections (HIV, hepatitis B/C, syphilis) and you do not have Sjögren’s syndrome or a similar condition that affects saliva.
- You are not allergic to mice or gentamicin, and you are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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