Tested aerosol chemotherapy inside the abdomen for stomach cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial looks at a way to give chemotherapy into the abdomen (through a small tube during laparoscopy) for certain stomach cancers. It aims to see whether this approach improves cancer control and surgical outcomes for people whose tumors can potentially be removed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stomach adenocarcinoma that is operable and can be surgically removed, staged as T3 or T4, and no distant spread (M0).
- You have NOT had chemotherapy or targeted cancer medicines before starting this study.
- You have NOT had any prior surgery that removed part or all of the tumor.
- Your scans (CT/MRI, plus other tests as needed) must show no distant metastases and no spread into nearby organs, and laparoscopy must show no cancer coating the abdominal lining (peritoneal carcinomatosis).
- Your blood counts and organ function (kidneys, liver) must meet required ranges, and your heart must be in acceptable condition.
- If you can become pregnant (or can have someone pregnant), you must use highly effective birth control during the study, and you must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests a new way to deliver chemotherapy inside the abdomen (belly) using a pressurized aerosol during a procedure, along with standard blood (IV) chemotherapy. It may help people with advanced ovarian cancer whose tumors have not progressed but are not removable with surgery yet.
This trial tests whether adding a special type of chemotherapy sprayed directly into the abdomen (PIPAC) to standard chemotherapy is safer and works better for stomach cancer that has spread only to the lining of the abdomen.
This trial tests adding the chemotherapy drug paclitaxel directly into the abdomen (intraperitoneal) along with standard IV chemotherapy for people with stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen. The goal is to see if this combination helps control the cancer better than standard treatment alone.
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
This trial tests a combination of heated chemotherapy given directly into the belly (HIPEC), standard chemotherapy (SOX), and an immunotherapy drug (sintilimab) for people with advanced stomach cancer that has spread to the lining of the abdomen. The goal is to see if this triple therapy can shrink or control the cancer better than standard treatments.
This trial compares standard laparoscopic surgery for stomach cancer versus the same surgery plus HIPEC, which is heated chemotherapy placed in the abdomen during the operation. It aims to see if adding the heated chemotherapy improves outcomes for people with higher-stage stomach cancer.
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