Compare reflux after bypass versus sleeve stomach surgery
Part of Digestive system, Hormones & metabolism clinical trials.
This study compares two weight-loss surgeries—gastric bypass and sleeve gastrectomy—to see which one causes less acid reflux afterward. It may help you by tailoring which surgery is better for people with reflux symptoms before surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are willing to be randomly assigned to either bypass or sleeve surgery
- You can understand and sign consent, and you can follow study visits and instructions
- You are between 18 and 70 years old
- Your body mass index (BMI) is high enough for bariatric surgery (BMI 35+ with other health issues, or BMI 40+)
- You currently have reflux/heartburn with a GERDQ score of at least 3, and your reflux severity is mild to moderate
- You take a proton pump inhibitor (acid-reducing medicine) and you have esophagitis grades A through D
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a modified version of sleeve gastrectomy that aims to reduce the risk of acid reflux (GERD) after surgery. It is for people aged 18–65 with a BMI between 35 and 55 who already have some degree of GERD and are planning to have weight loss surgery.
This study checks whether a surgical “fix” (omentumpexy) can reduce acid reflux after sleeve gastrectomy. It’s mainly for adults having sleeve surgery who have a higher-risk body weight and related health problems.
This study follows people for up to 8 years to see how two different weight-loss surgeries affect ongoing heartburn and acid reflux. You would join only if you were already enrolled in an earlier related study and can complete required follow-up visits and tests.
This study looks at complications after a type of weight-loss surgery called sleeve gastrectomy (removing part of the stomach). If you are considering this surgery and meet the weight/health guidelines, you may be able to join to help doctors learn more about risks and recovery.
This study looks at whether taking a common heartburn medicine (proton pump inhibitor) affects the long-term results of a weight-loss procedure called Endoscopic Sleeve Gastroplasty (ESG). It might help you if you are planning to have ESG or have already had it and want to understand how acid-reducing drugs could impact your recovery and weight loss.
This trial tests how well esomeprazole (a acid-reducing medicine) works after a Roux-en-Y gastric bypass, and how it changes the acidity in the stomach pouch. It may help confirm the best way to control stomach acid after bypass surgery.
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