Chemotherapy before surgery for certain soft tissue sarcomas
Treatments studied
Part of Cancer clinical trials.
This trial tests a step-by-step (sequential) chemotherapy plan given before surgery for adults with specific types of soft tissue sarcoma. The goal is to shrink or control the tumor before the operation and see how well this approach works and is tolerated.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and can sign consent
- Your diagnosis is a specific type of soft tissue sarcoma (a listed subtype)
- Your tumor is high grade (grade 2 or higher) and can be sampled with a biopsy
- The tumor is in an arm/leg area, the torso wall, or the “girdle,” and measures at least 5 cm
- There is no spread to other organs (metastasis) on scans, aside from small unclear lung spots
- Your health tests are strong enough (blood counts, kidney function, heart function) and you are not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
This Phase 3 trial tests whether giving chemotherapy around the time of surgery (before/after) can improve outcomes for people with high-risk localized soft-tissue sarcoma. It uses special tumor testing (CINSARC) to help identify higher-risk patients who may benefit.
This trial tests a new immunotherapy drug (envafolimab) combined with two chemotherapy drugs (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior treatment. The goal is to see if this combination is safe and effective.
This trial studies a shorter-course proton radiation plan given before surgery for certain soft tissue sarcomas. The goal is to treat the tumor locally while helping surgery be safer or more effective.
This trial tests if a powerful type of radiation called carbon ion therapy, given before surgery, is safe and effective for treating soft tissue sarcoma. It may help shrink the tumor before it’s removed.
This trial tests a shorter course of radiation (just 5 days) before surgery for soft tissue sarcoma. The goal is to see if a brief, high-dose radiation schedule works as well as or better than the usual longer course—and may be more convenient for you.
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